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Cyclic AMP-dependent transcription factor ATF-4

Summary

UniProt ID

P18848

Gene Symbol

ATF4
CREB2
TXREB

Organism

Homo sapiens (human)

External Links

GlyGen: P18848
PubChem: P18848
The Human Metabolome Database: HMDBP08114
The O-GlcNAc Database: P18848

Annotation

Keyword

3D-structure
Acetylation
Activator
Biological rhythms
Cell membrane
Coiled coil
Cytoskeleton
DNA-binding
Hydroxylation
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repressor
Transcription regulation
Ubl conjugation

Gene Ontology (GO)

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GO Term
gluconeogenesis
intracellular calcium ion homeostasis
gamma-aminobutyric acid signaling pathway
response to toxic substance
positive regulation of gene expression
neuron differentiation
bone mineralization
response to nutrient levels
negative regulation of translational initiation in response to stress
cellular response to oxidative stress

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GO Term
nuclear speck
cytosol
nuclear periphery
nucleoplasm
centrosome
RNA polymerase II transcription regulator complex

Displaying entries **11 - 17** of 17 in total

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GO Term
leucine zipper domain binding
protein heterodimerization activity
transcription cis-regulatory region binding
RNA polymerase II transcription regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA-binding transcription factor activity

Annotation information from UniProt.

Sequence

MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSEWLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTCDLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSLELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRGSPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKRAEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
ATF4 activates genes in response to endoplasmic reticulum stress	Homo sapiens
ATF6 (ATF6-alpha) activates chaperone genes	Homo sapiens
NFE2L2 regulating ER-stress associated genes	Homo sapiens
NFE2L2 regulating anti-oxidant/detoxification enzymes	Homo sapiens
PERK regulates gene expression	Homo sapiens
Response of EIF2AK1 (HRI) to heme deficiency	Homo sapiens
Response of EIF2AK4 (GCN2) to amino acid deficiency	Homo sapiens