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MIRAGE
Tumor necrosis factor receptor superfamily member 1A
Summary
- UniProt ID
- P19438
- Gene Symbol
-
- TNFAR
- TNFR1
- TNFRSF1A
- Gene ID
- 7132
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011588
- GlyGen
- P19438
- PubChem
- P19438
- Re-Glyco
- P19438
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Amyloidosis
- Apoptosis
- Cell membrane
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Golgi apparatus
- Host-virus interaction
- Receptor
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| tumor necrosis factor receptor activity |
| tumor necrosis factor binding |
| signaling receptor activity |
Sequence
MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 54 | N-linked (GlcNAc...) asparagine | |||
| 145 | N-linked (GlcNAc...) asparagine |
|
||
| 151 | N-linked (GlcNAc...) asparagine |
|
||
| 276 |
|
|
||
| 376 | (Microbial infection) N-beta-linked (GlcNAc) arginine |
|
G80920RR
G62765YT
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Interleukin-10 signaling | Homo sapiens |
| Regulation of TNFR1 signaling | Homo sapiens |
| TNF signaling | Homo sapiens |
| TNFR1-induced NF-kappa-B signaling pathway | Homo sapiens |
| TNFR1-induced proapoptotic signaling | Homo sapiens |
| TNFR1-mediated ceramide production | Homo sapiens |
| TNFs bind their physiological receptors | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0090018 | TNF receptor–associated periodic syndrome | |
| DOID:13141 | uveitis | |
| DOID:13166 | allergic bronchopulmonary aspergillosis | |
| DOID:2377 | multiple sclerosis | |
| DOID:2986 | IgA glomerulonephritis | |
| DOID:3355 | fibrosarcoma | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:6543 | acne | |
| DOID:7148 | rheumatoid arthritis |
