Interleukin-10 signaling

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PTGS2 genePTGS2IL10IL10 dimerIL10RA:JAK1IL10 dimer:2xIL10RA:JAK1IL10RB:TYK2IL10 ligand/receptor complexADPIL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2ATPIL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3STAT3IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3STAT32x(p-Y705-STAT3)2x(p-Y705-STAT3)IL10-downregulated genes for extracellular proteinsIL10-downregulated extracellular proteinsIL10-downregulated plasma membrane-associated genesIL10-downregulated plasma membrane proteinsTNFRSF1A gene, TIMP1 geneTNFRSF1A(41-201),TIMP1IL10-upregulated genes for plasma membrane proteinsIL10-upregulated plasma membrane proteins
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying all 2 entries
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_000766 P06734 Low affinity immunoglobulin epsilon Fc receptor view
GL_002323 P05362 Intercellular adhesion molecule 1 view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025