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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Myelin-associated glycoprotein
Summary
- UniProt ID
- P20916
- Gene Symbol
-
- MAG
- GMA
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P20916
- PubChem
- P20916
- The Human Metabolome Database
- HMDBP14367
- The O-GlcNAc Database
- P20916
- O-GlcNAcAtlas
- P20916
Annotation
- Keyword
-
- Alternative splicing
- Cell adhesion
- Cell membrane
- Disease variant
- Disulfide bond
- Glycoprotein
- Hereditary spastic paraplegia
- Immunoglobulin domain
- Lectin
- Lipid-binding
- Palmitate
- Phosphoprotein
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| negative regulation of neuron apoptotic process |
| negative regulation of neuron differentiation |
| positive regulation of astrocyte differentiation |
| GO Term |
|---|
| plasma membrane |
| myelin sheath |
| compact myelin |
| Schmidt-Lanterman incisure |
| membrane raft |
| paranode region of axon |
| myelin sheath adaxonal region |
| mesaxon |
| GO Term |
|---|
| protein homodimerization activity |
| sialic acid binding |
| signaling receptor binding |
| protein kinase binding |
| carbohydrate binding |
| ganglioside GT1b binding |
- Site Annotations
| Position | Description |
|---|---|
| 332 | Not glycosylated |
Sequence
MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 99 | N-linked (GlcNAc...) asparagine |
|
||
| 101 |
|
|||
| 106 | N-linked (GlcNAc...) asparagine; partial | |||
| 223 | N-linked (GlcNAc...) asparagine |
|
||
| 246 | N-linked (GlcNAc...) asparagine |
|
||
| 315 | N-linked (GlcNAc...) asparagine |
|
||
| 406 | N-linked (GlcNAc...) asparagine |
|
||
| 450 | N-linked (GlcNAc...) asparagine |
|
||
| 454 | N-linked (GlcNAc...) asparagine |
|
G49108TO
G02815KT
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Axonal growth inhibition (RHOA activation) | Homo sapiens |
| Basigin interactions | Homo sapiens |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060600 | obsolete hereditary motor and sensory neuropathy with agenesis of the corpus callosum | |
| DOID:0060776 | congenital diarrhea 5 with tufting enteropathy | |
| DOID:0060843 | hereditary neuropathy with liability to pressure palsies | |
| DOID:0060891 | Parkinson's disease 19A | |
| DOID:0060895 | Parkinson's disease 4 | |
| DOID:0060896 | Parkinson's disease 23 | |
| DOID:0070161 | hereditary sensory and autonomic neuropathy type 2 | |
| DOID:0080067 | Charcot-Marie-Tooth disease type 5 | |
| DOID:0080348 | Alzheimer's disease 1 | |
| DOID:0090003 | agenesis of the corpus callosum with peripheral neuropathy |
