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Beta-nerve growth factor

Summary

UniProt ID

P25427

Gene Symbol

Ngf
Ngfb

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P25427

Annotation

Keyword

Cleavage on pair of basic residues
Disulfide bond
Endosome
Glycoprotein
Growth factor
Lipid-binding
Metalloprotease inhibitor
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 53 in total

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GO Term
response to ozone
cell proliferation in forebrain
positive regulation of collateral sprouting
extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of type B pancreatic cell apoptotic process
sensory perception of hot stimulus
positive regulation of protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors

Displaying **all 8** entries
GO Term
endoplasmic reticulum lumen
Golgi lumen
extracellular region
extracellular space
axon
dendrite
synaptic vesicle
endosome lumen

Displaying **all 5** entries
GO Term
nerve growth factor receptor binding
transmembrane receptor protein tyrosine kinase activator activity
growth factor activity
metalloendopeptidase inhibitor activity
lipid binding

Annotation information from UniProt.

Sequence

MSMLFYTLITAFLIGVQAEPYTDSNVPEGDSVPEAHWTKLQHSLDTALRRARSAPAEPIAARVTGQTRNITVDPKLFKKRRLRSPRVLFSTQPPPTSSDTLDLDFQAHGTISFNRTHRSKRSSTHPVFHMGEFSVCDSVSVWVGDKTTATDIKGKEVTVLGEVNINNSVFKQYFFETKCRAPNPVESGCRGIDSKHWNSYCTTTHTFVKALTTDDKQAAWRFIRIDTACVCVLSRKAARRG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
69	N-linked (GlcNAc...) asparagine	UniProt
114	N-linked (GlcNAc...) asparagine	UniProt
166	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 12 in total

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Pathway Name	Organism
ARMS-mediated activation	Rattus norvegicus
Axonal growth stimulation	Rattus norvegicus
Frs2-mediated activation	Rattus norvegicus
NADE modulates death signalling	Rattus norvegicus
NF-kB is activated and signals survival	Rattus norvegicus
NFG and proNGF binds to p75NTR	Rattus norvegicus
NGF processing	Rattus norvegicus
NRIF signals cell death from the nucleus	Rattus norvegicus
PI3K/AKT activation	Rattus norvegicus
Retrograde neurotrophin signalling	Rattus norvegicus