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Nuclear factor NF-kappa-B p105 subunit

Summary

UniProt ID

P25799

Gene Symbol

Nfkb1

Organism

Mus musculus (house mouse)

External Links

GlyGen: P25799
PubChem: P25799
The O-GlcNAc Database: P25799
O-GlcNAcAtlas: P25799

Annotation

Keyword

3D-structure
ANK repeat
Acetylation
Activator
Alternative splicing
Apoptosis
Cytoplasm
DNA-binding
Direct protein sequencing
Hydroxylation
Isopeptide bond
Lipoprotein
Nucleus
Phosphoprotein
Reference proteome
Repeat
S-nitrosylation
Transcription regulation
Ubl conjugation

Gene Ontology (GO)

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GO Term
negative regulation of cytokine production
apoptotic process
inflammatory response
response to oxidative stress
gene expression
positive regulation of gene expression
innate immune response
negative regulation of inflammatory response
response to organic cyclic compound
response to cytokine

Displaying **all 9** entries
GO Term
chromatin
nucleus
cytoplasm
protein-containing complex
mitochondrion
cytosol
nucleoplasm
transcription regulator complex
NF-kappaB p50/p65 complex

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GO Term
DNA binding
chromatin binding
protein-containing complex binding
heat shock protein binding
identical protein binding
actinin binding
transcription cis-regulatory region binding
RNA polymerase II transcription regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription repressor activity, RNA polymerase II-specific

Annotation information from UniProt.

Sequence

MADDDPYGTGQMFHLNTALTHSIFNAELYSPEIPLSTDGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGVCTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHSDLAYLQAEGGGDRQLTDREKEIIRQAAVQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTIKELMEALQQMGYTEAIEVIQAAFRTPATTASSPVTTAQVHCLPLSSSSTRQHIDELRDSDSVCDSGVETSFRKLSFTESLTGDSPLLSLNKMPHGYGQEGPIEGKI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	GlyTouCan ID	Source
890	G49108TO	GlyGen The O-GlcNAc Database
893	G49108TO	GlyGen
894	G49108TO	GlyGen
901	G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Activation of NF-kappaB in B cells	Mus musculus
CD209 (DC-SIGN) signaling	Mus musculus
CLEC7A (Dectin-1) signaling	Mus musculus
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	Mus musculus
Downstream TCR signaling	Mus musculus
FCERI mediated NF-kB activation	Mus musculus
Interleukin-1 processing	Mus musculus
Interleukin-1 signaling	Mus musculus
MAP3K8 (TPL2)-dependent MAPK1/3 activation	Mus musculus
NF-kB is activated and signals survival	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Annotation

International Collaboration

Acknowledgements