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Interleukin-12 subunit alpha

Summary

UniProt ID

P29459

Gene Symbol

IL12A
NKSF1

Gene ID

3592

Organism

Homo sapiens (human)

External Links

PubChem: P29459
Re-Glyco: P29459

Annotation

Keyword

3D-structure
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor
Host-virus interaction
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying **all 5** entries
GO Term
endoplasmic reticulum lumen
late endosome lumen
interleukin-12 complex
extracellular region
extracellular space

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 26 in total

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GO Term
immune response
response to virus
cell migration
positive regulation of type II interferon production
positive regulation of mononuclear cell proliferation
positive regulation of cell adhesion
positive regulation of lymphocyte proliferation
negative regulation of protein secretion
defense response to Gram-positive bacterium
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

Displaying **all 6** entries
GO Term
interleukin-12 receptor binding
interleukin-12 beta subunit binding
interleukin-27 binding
cytokine activity
growth factor activity
protein heterodimerization activity

Annotation information from UniProt.

Sequence

MCPARSLLLVATLVLLDHLSLARNLPVATPDPGMFPCLHHSQNLLRAVSNMLQKARQTLEFYPCTSEEIDHEDITKDKTSTVEACLPLELTKNESCLNSRETSFITNGSCLASRKTSFMMALCLSSIYEDLKMYQVEFKTMNAKLLMDPKRQIFLDQNMLAVIDELMQALNFNSETVPQKSSLEEPDFYKTKIKLCILLHAFRIRAVTIDRVMSYLNAS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
93	N-linked (GlcNAc...) asparagine			UniProt
107	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Interleukin-10 signaling	Homo sapiens
Interleukin-12 signaling	Homo sapiens
Interleukin-35 Signalling	Homo sapiens
Interleukin-4 and Interleukin-13 signaling	Homo sapiens

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:12236	primary biliary cholangitis	Alliance of Genome Resources
DOID:1883	hepatitis C	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources