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Cyclin-dependent kinase 4

Summary

UniProt ID

P30285

Gene Symbol

Cdk4
Crk3

Organism

Mus musculus (house mouse)

External Links

GlyGen: P30285
PubChem: P30285
The O-GlcNAc Database: P30285

Annotation

Keyword

ATP-binding
Acetylation
Cell division
Cytoplasm
Membrane
Nucleus
Phosphoprotein
Proto-oncogene
Reference proteome
Serine/threonine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 10** of 23 in total

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GO Term
positive regulation of cell size
response to xenobiotic stimulus
G1/S transition of mitotic cell cycle
response to lead ion
signal transduction
positive regulation of cell population proliferation
response to organic substance
regulation of gene expression
phosphorylation
positive regulation of epithelial cell proliferation

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GO Term
cytosol
cyclin-dependent protein kinase holoenzyme complex
nucleoplasm
transcription regulator complex
perinuclear region of cytoplasm
cyclin D1-CDK4 complex
cyclin D2-CDK4 complex
cyclin D3-CDK4 complex
chromatin
nucleus

Displaying **all 7** entries
GO Term
protein kinase activity
kinase activity
protein-containing complex binding
cyclin binding
cyclin-dependent protein serine/threonine kinase activity
ATP binding
protein serine kinase activity

Annotation information from UniProt.

Sequence

MAATRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLPRGAFAPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKEESDAE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 11 in total

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Pathway Name	Organism
Cyclin D associated events in G1	Mus musculus
Drug-mediated inhibition of CDK4/CDK6 activity	Mus musculus
Oncogene Induced Senescence	Mus musculus
Oxidative Stress Induced Senescence	Mus musculus
PTK6 Regulates Cell Cycle	Mus musculus
RMTs methylate histone arginines	Mus musculus
SCF(Skp2)-mediated degradation of p27/p21	Mus musculus
Senescence-Associated Secretory Phenotype (SASP)	Mus musculus
Transcriptional regulation by RUNX2	Mus musculus
Transcriptional regulation of granulopoiesis	Mus musculus