Oxidative Stress Induced Senescence

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
p-MAPK8,9,10p-MAPK8,9,10JunADPP05627ATPp-2S-cJUN:p-2S,2T-cFOSP01101TP53 Tetramerp-S37-TP53 TetramerEzh2PRC2 (EZH2) CoreRbbp4Suz12EedRbbp7p38 MAPK:MAPKAPK5phospho-p38 MAPK: MAPKAPK5ATPMAPK8,9,10ADPp-MKK3,p-MKK6p-MKK3,p-MKK6p-p38 MAPK: MAPKAPK2,3p38 MAPK:MAPKAPK2,3p-p38 MAPK:p-MAPKAPK2/3Fosp-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53PolyUb-TP53 Tetramerp-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4UbCDK4,CDK6CDK4,CDK6:INK4Cdkn2bMAP3K5:TXNMAP3K5ROSTxnMKK3, MKK6KDM6BKDM6B:Fe2+Fe2+phospho-p38 MAPK:p-T-182-MAPKAPK5
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: February 17, 2025