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RAC-alpha serine/threonine-protein kinase
Summary
- UniProt ID
- P31749
- Gene Symbol
-
- AKT1
- PKB
- RAC
- Gene ID
- 207
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Apoptosis
- Cell membrane
- Cytoplasm
- Developmental protein
- Disease variant
- Disulfide bond
- Glucose metabolism
- Glycogen biosynthesis
- Glycogen metabolism
- Glycoprotein
- Isopeptide bond
- Mitochondrion
- Neurogenesis
- Nucleus
- Phosphoprotein
- Proto-oncogene
- Reference proteome
- Serine/threonine-protein kinase
- Sugar transport
- Translation regulation
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| nucleus |
| cytoplasm |
| plasma membrane |
| cell-cell junction |
| cell cortex |
| membrane |
| vesicle |
| protein-containing complex |
| nucleoplasm |
| glutamatergic synapse |
| GO Term |
|---|
| histone H2AS121 kinase activity |
| DNA-dependent protein kinase activity |
| histone H2AXS139 kinase activity |
| histone H2BS14 kinase activity |
| histone H2BS36 kinase activity |
| histone H3T45 kinase activity |
| histone H3S57 kinase activity |
Sequence
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 126 | O-linked (GlcNAc) serine; alternate | |||
| 129 | O-linked (GlcNAc) serine; alternate | |||
| 305 | O-linked (GlcNAc) threonine | |||
| 308 |
|
|||
| 312 | O-linked (GlcNAc) threonine | |||
| 473 | O-linked (GlcNAc) serine; alternate |
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| AKT phosphorylates targets in the cytosol | Homo sapiens |
| AKT phosphorylates targets in the nucleus | Homo sapiens |
| AKT-mediated inactivation of FOXO1A | Homo sapiens |
| Activation of BAD and translocation to mitochondria | Homo sapiens |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | Homo sapiens |
| CD28 dependent PI3K/Akt signaling | Homo sapiens |
| CTLA4 inhibitory signaling | Homo sapiens |
| Constitutive Signaling by AKT1 E17K in Cancer | Homo sapiens |
| Cyclin A:Cdk2-associated events at S phase entry | Homo sapiens |
| Cyclin E associated events during G1/S transition | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease | |
| DOID:0081002 | Cowden syndrome 6 | |
| DOID:10283 | prostate cancer | |
| DOID:1107 | esophageal carcinoma | |
| DOID:13482 | Proteus syndrome | |
| DOID:14330 | Parkinson's disease | |
| DOID:1612 | breast cancer | |
| DOID:1793 | pancreatic cancer | |
| DOID:219 | colon cancer | |
| DOID:2394 | ovarian cancer |
