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RAC-beta serine/threonine-protein kinase
Summary
- UniProt ID
- P31751
- Gene Symbol
-
- AKT2
- Gene ID
- 208
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P31751
- PubChem
- P31751
- The Human Metabolome Database
- HMDBP01319
- Re-Glyco
- P31751
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Apoptosis
- Cell membrane
- Cytoplasm
- Developmental protein
- Diabetes mellitus
- Disease variant
- Disulfide bond
- Endosome
- Glucose metabolism
- Glycogen biosynthesis
- Glycogen metabolism
- Glycoprotein
- Manganese
- Metal-binding
- Nucleus
- Phosphoprotein
- Proteomics identification
- Proto-oncogene
- Reference proteome
- Serine/threonine-protein kinase
- Sugar transport
- Translation regulation
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| cell cortex |
| nucleoplasm |
| early endosome |
| cytosol |
| ruffle membrane |
| nucleus |
| cytoplasm |
| plasma membrane |
| intracellular membrane-bounded organelle |
| GO Term |
|---|
| histone H2AS1 kinase activity |
| Rho-dependent protein serine/threonine kinase activity |
| molecular function activator activity |
| protein serine/threonine kinase activity |
| ATP binding |
Sequence
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 128 | O-linked (GlcNAc) serine |
|
||
| 131 | O-linked (GlcNAc) serine |
|
||
| 306 | O-linked (GlcNAc) threonine |
|
||
| 313 | O-linked (GlcNAc) threonine |
|
||
| 474 | O-linked (GlcNAc) serine; alternate |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| AKT phosphorylates targets in the cytosol | Homo sapiens |
| AKT phosphorylates targets in the nucleus | Homo sapiens |
| AKT-mediated inactivation of FOXO1A | Homo sapiens |
| Activation of BAD and translocation to mitochondria | Homo sapiens |
| Activation of PKB | Homo sapiens |
| CD28 dependent PI3K/Akt signaling | Homo sapiens |
| CTLA4 inhibitory signaling | Homo sapiens |
| Constitutive Signaling by AKT1 E17K in Cancer | Homo sapiens |
| Cyclin A:Cdk2-associated events at S phase entry | Homo sapiens |
| Cyclin E associated events during G1/S transition | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0112263 | hypoinsulinemic hypoglycemia with hemihypertrophy | |
| DOID:10283 | prostate cancer | |
| DOID:10286 | prostate carcinoma | |
| DOID:1380 | endometrial cancer | |
| DOID:2526 | prostate adenocarcinoma | |
| DOID:4001 | ovarian carcinoma | |
| DOID:9352 | type 2 diabetes mellitus | |
| DOID:9993 | hypoglycemia |
