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Receptor-type tyrosine-protein kinase FLT3

Summary

UniProt ID

P36888

Gene Symbol

FLT3
CD135
FLK2
STK1

Organism

Homo sapiens (human)

External Links

GlyGen: P36888
PubChem: P36888
The Human Metabolome Database: HMDBP01189

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Disease variant
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Host-virus interaction
Immunoglobulin domain
Phosphoprotein
Proto-oncogene
Receptor
Reference proteome
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

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GO Term
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
leukocyte homeostasis
myeloid progenitor cell differentiation
pro-B cell differentiation
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell population proliferation
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
hemopoiesis

Displaying **all 5** entries
GO Term
plasma membrane
receptor complex
endoplasmic reticulum
endosome membrane
endoplasmic reticulum lumen

Displaying **all 10** entries
GO Term
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
cytokine receptor activity
protein-containing complex binding
nuclear glucocorticoid receptor binding
vascular endothelial growth factor receptor activity
ATP binding
growth factor binding
protein self-association
phosphatidylinositol 3-kinase activator activity

Annotation information from UniProt.

Sequence

MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
43	N-linked (GlcNAc...) asparagine	21389326		UniProt GlyGen
100	N-linked (GlcNAc...) asparagine	21389326		UniProt GlyGen
151	N-linked (GlcNAc...) asparagine	21389326		UniProt GlyGen
306	N-linked (GlcNAc...) asparagine	21389326		UniProt GlyGen
323	N-linked (GlcNAc...) asparagine	21389326	G80920RR	UniProt GlyGen
351	N-linked (GlcNAc...) asparagine	21389326		UniProt GlyGen
354	N-linked (GlcNAc...) asparagine	21389326		UniProt GlyGen
473				UniProt GlyGen
502				UniProt GlyGen
541	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 27 in total

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Pathway Name	Organism
Constitutive Signaling by Aberrant PI3K in Cancer	Homo sapiens
FLT3 Signaling	Homo sapiens
FLT3 mutants bind TKIs	Homo sapiens
FLT3 signaling by CBL mutants	Homo sapiens
FLT3 signaling through SRC family kinases	Homo sapiens
KW2449-resistant FLT3 mutants	Homo sapiens
Negative regulation of FLT3	Homo sapiens
PI3K Cascade	Homo sapiens
PI3K/AKT Signaling	Homo sapiens
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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International Collaboration

Acknowledgements