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TGF-beta receptor type-1

Summary

UniProt ID

P36897

Gene Symbol

TGFBR1
ALK5
SKR4

Organism

Homo sapiens (human)

External Links

GlyGen: P36897
PubChem: P36897
The Human Metabolome Database: HMDBP01288

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Aortic aneurysm
Apoptosis
Cell membrane
Craniosynostosis
Differentiation
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Growth regulation
Isopeptide bond
Magnesium
Manganese
Metal-binding
Phosphoprotein
Receptor
Reference proteome
Serine/threonine-protein kinase
Signal
Tight junction
Transmembrane helix
Ubl conjugation

Gene Ontology (GO)

Displaying entries **31 - 40** of 73 in total

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GO Term
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
positive regulation of SMAD protein signal transduction
peptidyl-serine phosphorylation
regulation of protein ubiquitination
activin receptor signaling pathway
filopodium assembly
regulation of DNA-templated transcription
positive regulation of DNA-templated transcription
ventricular compact myocardium morphogenesis
transforming growth factor beta receptor signaling pathway

Displaying **all 10** entries
GO Term
receptor complex
activin receptor complex
membrane raft
endosome
nucleus
plasma membrane
bicellular tight junction
membrane
cell surface
transforming growth factor beta ligand-receptor complex

Displaying entries **1 - 10** of 14 in total

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GO Term
activin receptor activity, type I
ubiquitin protein ligase binding
activin binding
SMAD binding
transmembrane receptor protein serine/threonine kinase activity
transforming growth factor beta receptor activity
transforming growth factor beta receptor activity, type I
type II transforming growth factor beta receptor binding
ATP binding
protein kinase activity

Annotation information from UniProt.

Sequence

MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	GlyTouCan ID	Source
45	N-linked (GlcNAc...) asparagine	G80920RR	UniProt GlyGen
92		G57321FI	GlyGen
344		G80920RR	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
Downregulation of TGF-beta receptor signaling	Homo sapiens
SMAD2/3 Phosphorylation Motif Mutants in Cancer	Homo sapiens
TGF-beta receptor signaling activates SMADs	Homo sapiens
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	Homo sapiens
TGFBR1 KD Mutants in Cancer	Homo sapiens
TGFBR1 LBD Mutants in Cancer	Homo sapiens
TGFBR2 Kinase Domain Mutants in Cancer	Homo sapiens
UCH proteinases	Homo sapiens
Ub-specific processing proteases	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements