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Interleukin-6 receptor subunit beta

Summary

UniProt ID

P40189

Gene Symbol

IL6ST

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011673

GlyConnect

GlyGen

P40189

PubChem

P40189

The O-GlcNAc Database

P40189

O-GlcNAcAtlas

P40189

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Host-virus interaction
Immunoglobulin domain
Phosphoprotein
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Gene Ontology (GO)

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GO Term
positive regulation of Notch signaling pathway
positive regulation of acute inflammatory response
positive regulation of adaptive immune response
glycogen metabolic process
positive regulation of cell population proliferation
cytokine-mediated signaling pathway
response to cytokine
positive regulation of T cell proliferation
negative regulation of apoptotic process
positive regulation of platelet aggregation

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GO Term
extracellular exosome
interleukin-6 receptor complex
oncostatin-M receptor complex
ciliary neurotrophic factor receptor complex
external side of plasma membrane
extracellular region
extracellular space
plasma membrane
membrane
dendrite

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GO Term
interleukin-11 receptor activity
interleukin-11 binding
protein tyrosine kinase activator activity
cytokine receptor activity
ciliary neurotrophic factor receptor binding
coreceptor activity
growth factor binding
cytokine binding
identical protein binding
scaffold protein binding

Annotation information from UniProt.

Sequence

MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSVNEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEGMPKSYLPQTVRQGGYMPQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
43	N-linked (GlcNAc...) asparagine	11098061 20489211		UniProt GlyGen
83	N-linked (GlcNAc...) asparagine	11098061 20489211	G27058EU G83460ZZ G59626AS G08290VR G01650EU G70101JE G80920RR G63041LO G45504EY G29299MO G37399XV G47644PP G10486CT G28541PG G95865ZB G31852PQ G02815KT	UniProt GlyGen GlyConnect
131	N-linked (GlcNAc...) asparagine	11098061	G38663NM G56784JY G81263BG G45395BF G08918WF G87661QW G04657PL G27058EU G84452RH G41071NU G80920RR G90659AW G62765YT G92275SC	UniProt GlyGen GlyConnect
133			G49108TO	GlyGen The O-GlcNAc Database
157	N-linked (GlcNAc...) asparagine	11098061	G43089EG G37881RL G52527GH G28622IK G56784JY G45395BF G59536GA G08918WF G00912UN G27058EU G59626AS G42124LM G62765YT G72790NZ G10486CT	UniProt GlyGen GlyConnect
227	N-linked (GlcNAc...) asparagine	11098061 19159218 20489211	G92275SC	UniProt GlyGen
246			G43089EG G33791AF	GlyGen GlyConnect
379	N-linked (GlcNAc...) asparagine	11098061 16335952	G22310AV G82830MN G80920RR G32550BI	GlycoProtDB UniProt GlyGen GlyConnect
383	N-linked (GlcNAc...) asparagine	11098061 16335952 20489211	G26436YP	GlycoProtDB UniProt GlyGen
390	N-linked (GlcNAc...) (complex) asparagine	19139490 19159218	G55412XP G56784JY G45395BF G41071NU G80920RR G90659AW G62765YT G72787SB G81295CK	UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
IL-6-type cytokine receptor ligand interactions	Homo sapiens
Interleukin-27 signaling	Homo sapiens
Interleukin-35 Signalling	Homo sapiens
Interleukin-6 signaling	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

International Collaboration

Acknowledgements