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Interleukin-27 signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9020956

PubChem

R-HSA-9020956

Description

Interleukin-27 (IL27) is a heterodimeric cytokine that contains Epstein-Barr virus–induced gene 3 (EBI3) and IL27p28 (IL27). It signals through a receptor composed of Interleukin-6 receptor subunit beta (IL6ST, gp130), which is utilized by many cytokines, and Interleukin-27 receptor subunit alpha (IL27RA, WSX-1, TCCR) (Yoshida & Hunter 2015).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 9** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O75462	Cytokine receptor-like factor 1	CRLF1 UNQ288/PRO327	view
P23458	Tyrosine-protein kinase JAK1	JAK1 JAK1A JAK1B	view
P27824	Calnexin	CANX	view
P29597	Non-receptor tyrosine-protein kinase TYK2	TYK2	view
P40189	Interleukin-6 receptor subunit beta	IL6ST	view
P40763	Signal transducer and activator of transcription 3	APRF STAT3	view
P42224	Signal transducer and activator of transcription 1-alpha/beta	STAT1	view
Q14213	Interleukin-27 subunit beta	EBI3 IL27B	view
Q6UWB1	Interleukin-27 receptor subunit alpha	CRL1 IL27RA TCCR UNQ296/PRO336 WSX1	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_000249	P27824	Calnexin	view

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