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Signal transducer and activator of transcription 3

Summary

UniProt ID

P42227

Gene Symbol

Aprf
Stat3

Gene ID

20848

Organism

Mus musculus (house mouse)

External Links

GlyGen: P42227
PubChem: P42227
The O-GlcNAc Database: P42227
RaftProt: P42227
O-GlcNAcAtlas: P42227
Re-Glyco: P42227

Annotation

Keyword

3D-structure
Acetylation
Activator
Acute phase
Alternative splicing
Cytoplasm
DNA-binding
Direct protein sequencing
Nucleus
Phosphoprotein
Reference proteome
SH2 domain
Transcription regulation

Gene Ontology (GO)

Displaying **all 9** entries
GO Term
nucleus
protein-containing complex
nucleoplasm
cytosol
transcription regulator complex
chromatin
cytoplasm
plasma membrane
RNA polymerase II transcription regulator complex

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
receptor signaling pathway via JAK-STAT
interleukin-11-mediated signaling pathway
interleukin-23-mediated signaling pathway
cellular response to leptin stimulus
radial glial cell differentiation
retinal rod cell differentiation
growth hormone receptor signaling pathway via JAK-STAT
T-helper 17 type immune response
cellular response to interleukin-17
interleukin-10-mediated signaling pathway

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GO Term
lncRNA binding
acetylation-dependent protein binding
signaling receptor binding
RNA sequestering activity
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA binding
DNA-binding transcription factor activity
protein kinase binding

Annotation information from UniProt.

Sequence

MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	GlyTouCan ID	Source
401	G97993TU	GlyGen
714	G49108TO	GlyGen The O-GlcNAc Database
716	G49108TO	GlyGen
717	G49108TO	GlyGen The O-GlcNAc Database
719	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **11 - 19** of 19 in total

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Pathway Name	Organism
Interleukin-6 signaling	Mus musculus
Interleukin-7 signaling	Mus musculus
Interleukin-9 signaling	Mus musculus
MET activates STAT3	Mus musculus
PKR-mediated signaling	Mus musculus
PTK6 Activates STAT3	Mus musculus
STAT3 nuclear events downstream of ALK signaling	Mus musculus
Signaling by ALK	Mus musculus
Signaling by SCF-KIT	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements