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MIRAGE
Interleukin-6 signaling

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Il6IL6:IL6R-2Il6raIl6stIL6:IL6R-2:IL6ST-2IL6:IL6RIL6RIL6R:IL6R inhibitorsIL6R inhibitorsIL6ST:JAK1, JAK2, (TYK2)IL6:sIL6R:IL6RB:JAKsIL6:IL6RA:IL6RB:JAKsIL6 receptor trimer:JAKsIL6 receptor hexamer:JAKsADPIL6 receptor hexamer:Activated JAKsATPTyrosine phosphorylated IL6 receptor hexamer:Activated JAKsTyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3STAT1, STAT3Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3p-Y701-STAT1, p-Y705-STAT3p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y701-STAT1:p-Y705-STAT3STAT1/3 homo and heterodimersPTPN11Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3Socs3Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBLCBL
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
a simple tooltip
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025