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Tyrosine-protein kinase JAK1

Summary

UniProt ID

P52332

Gene Symbol

Jak1

Organism

Mus musculus (house mouse)

External Links

GlyConnect

Tyrosine-protein kinase JAK1

GlyGen

P52332

PubChem

P52332

Re-Glyco

P52332

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Direct protein sequencing
Magnesium
Membrane
Metal-binding
Phosphoprotein
Reference proteome
Repeat
SH2 domain
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

Displaying **all 4** entries
GO Term
cytoskeleton
endomembrane system
membrane
cytosol

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 9** entries
GO Term
cytokine-mediated signaling pathway
intracellular signal transduction
receptor signaling pathway via JAK-STAT
cellular response to interleukin-3
cellular response to interleukin-7
response to antibiotic
enzyme-linked receptor protein signaling pathway
interleukin-2-mediated signaling pathway
positive regulation of receptor signaling pathway via STAT

Displaying **all 7** entries
GO Term
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
ATP binding
growth hormone receptor binding
histone H2AXY142 kinase activity
metal ion binding
histone H3Y41 kinase activity

Annotation information from UniProt.

Sequence

MQYLNIKEDCNAMAFCAKMRSFKKTEVKQVVPEPGVEVTFYLLDREPLRLGSGEYTAEELCIRAAQECSISPLCHNLFALYDESTKLWYAPNRIITVDDKTSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKRVPEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVHDLKVKYLATLETSTLTKHYGAEIFETSMLLISSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKRKKLEYNKHKKDDERNKLREEWNNFSYFPEITHIVIKESVVSINKQDNKNMELKLSSREEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSMDHFPSLRDLMNHLKKQILRTDNISFVLKRCCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYKDEEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPVSVLTRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKQPTTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVKTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGFEALLK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	GlyTouCan ID	Source
768	G06110VR	GlyGen GlyConnect
813		GlyGen
1094		GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 25 in total

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Pathway Name	Organism
IFNG signaling activates MAPKs	Mus musculus
IL-6-type cytokine receptor ligand interactions	Mus musculus
ISG15 antiviral mechanism	Mus musculus
Inactivation of CSF3 (G-CSF) signaling	Mus musculus
Interferon alpha/beta signaling	Mus musculus
Interferon gamma signaling	Mus musculus
Interleukin receptor SHC signaling	Mus musculus
Interleukin-10 signaling	Mus musculus
Interleukin-12 signaling	Mus musculus
Interleukin-15 signaling	Mus musculus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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International Collaboration

Acknowledgements