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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Summary
- UniProt ID
- P42338
- Gene Symbol
-
- PIK3CB
- PIK3C1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P42338
- PubChem
- P42338
- The Human Metabolome Database
- HMDBP01208
- The O-GlcNAc Database
- P42338
Annotation
- Keyword
-
- ATP-binding
- Autophagy
- Cell adhesion
- Cytoplasm
- Endocytosis
- Kinase
- Lipid metabolism
- Nucleus
- Phosphoprotein
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| regulation of clathrin-dependent endocytosis |
| negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway |
| endothelial cell proliferation |
| intracellular calcium ion homeostasis |
Sequence
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 478 |
|
|||
| 481 |
|
|||
| 485 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Constitutive Signaling by Aberrant PI3K in Cancer | Homo sapiens |
| DAP12 signaling | Homo sapiens |
| Downstream TCR signaling | Homo sapiens |
| Downstream signal transduction | Homo sapiens |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | Homo sapiens |
| GPVI-mediated activation cascade | Homo sapiens |
| IRS-mediated signalling | Homo sapiens |
| Interleukin receptor SHC signaling | Homo sapiens |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | Homo sapiens |
| Nephrin family interactions | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060642 | recessive dystrophic epidermolysis bullosa | |
| DOID:0060644 | chondrodysplasia-pseudohermaphroditism syndrome | |
| DOID:0060707 | lymphoproliferative syndrome 1 | |
| DOID:0060708 | lymphoproliferative syndrome 2 | |
| DOID:0060764 | autosomal recessive Robinow syndrome | |
| DOID:0060765 | autosomal dominant Robinow syndrome 2 | |
| DOID:0060766 | autosomal dominant Robinow syndrome 1 | |
| DOID:0060767 | autosomal dominant Robinow syndrome 3 | |
| DOID:0060782 | EEC syndrome | |
| DOID:0060783 | ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3 |
