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Integrin alpha-V

Summary

UniProt ID

P43406

Gene Symbol

Itgav

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003628

GlyConnect

2402

GlyGen

P43406

PubChem

P43406

The O-GlcNAc Database

P43406

Annotation

Keyword

Angiogenesis
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Integrin
Metal-binding
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

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GO Term
negative regulation of entry of bacterium into host cell
release of sequestered calcium ion into cytosol
focal adhesion assembly
negative regulation of lipid storage
positive regulation of small GTPase mediated signal transduction
cell-matrix adhesion
viral entry into host cell
positive regulation of cytosolic calcium ion concentration
integrin-mediated signaling pathway
negative chemotaxis

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GO Term
plasma membrane
membrane
lamellipodium membrane
filopodium membrane
microvillus membrane
cytosol
focal adhesion
integrin complex
external side of plasma membrane
cell surface

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GO Term
protease binding
signaling receptor binding
voltage-gated calcium channel activity
metal ion binding
extracellular matrix binding
extracellular matrix protein binding
C-X3-C chemokine binding
insulin-like growth factor I binding
fibronectin binding
fibroblast growth factor binding

Annotation information from UniProt.

Sequence

MAAPGRLLLRPRPGGLLLLLPGLLLPLADAFNLDVESPAEYAGPEGSYFGFAVDFFEPSTSSRMFLLVGAPKANTTQPGIVEGGQVLKCECSSSRRCQPIEFDSTGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSKNIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIISKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIEDFVSGVPRAARTLGMVYIYDGKNMSSLHNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRAVGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGLVYIFNGRSTGLNSVPSQILEGQWAAQSMPPSFGYSMKGATDVDRNGYPDLVVGAFGVDRAVLYRARPVVTVNAGLEVYPSILNQDNKICPLPGTALKVSCFNVRFCLKADGKGTLPRKLHFQVELLLDKLKQKGAIRRALFLHNRSPVHSKTMTVFRGGQMQCEELVAYLRDESEFRDKLTPITIFMEYRLDQRTAADATGLQPILNQFTPANVSRQAHILLDCGEDNVCKPKLEVSVNSDQKKIYIGDDNPLTLTVKAQNQGEGAYEAELIVSIPPQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLKIQSSNSFDNVSPVVSYKVDLAVLAAVEIRGVSSPDHIFLPIPNWEYKENPETEEDVGPIVQHIYELRNNGPSSFSKAILNLQWPYKYNNNTLLYILHYDIDGPMNCTADTEINPLRIKTPEKNDTAAAGQGERNHLITKRDLTLREGDVHTLGCGIAKCLQITCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNIIEFPYKNLPIEDLFNSTLVTTNITWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
74	N-linked (GlcNAc...) asparagine	19349973 19656770	G23863VK G64527OM G50045TK G05724UK G33609NS G39188ZX G57776ZU G06110VR G66538GV G14669DU G63628AV	GlycoProtDB UniProt GlyGen GlyConnect
290	N-linked (GlcNAc...) asparagine			UniProt GlyGen
296	N-linked (GlcNAc...) asparagine			UniProt GlyGen
546			G33609NS	GlyGen GlyConnect
615	N-linked (GlcNAc...) asparagine	19349973 19656770	G70101JE G80920RR G05724UK	GlycoProtDB UniProt GlyGen GlyConnect
704	N-linked (GlcNAc...) asparagine		G41247ZX	GlycoProtDB UniProt GlyGen
755			G02815KT	GlyGen
835	N-linked (GlcNAc...) asparagine		G56307ZW	GlycoProtDB UniProt GlyGen
851	N-linked (GlcNAc...) asparagine		G72065MN	GlycoProtDB UniProt GlyGen
869	N-linked (GlcNAc...) asparagine	19349973 19656770	G82347DR G14994KB G70101JE G74430RZ G64527OM G05724UK G39188ZX G06110VR	GlycoProtDB UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Cross-presentation of particulate exogenous antigens (phagosomes)	Mus musculus
ECM proteoglycans	Mus musculus
Elastic fibre formation	Mus musculus
Integrin cell surface interactions	Mus musculus
Molecules associated with elastic fibres	Mus musculus
Neutrophil degranulation	Mus musculus
PECAM1 interactions	Mus musculus
Signal transduction by L1	Mus musculus
Syndecan interactions	Mus musculus
TGF-beta receptor signaling activates SMADs	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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External Links

Annotation

International Collaboration

Acknowledgements