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E3 ubiquitin-protein ligase NEDD4

Summary

UniProt ID

P46935

Gene Symbol

Kiaa0093
Nedd-4
Nedd4
Nedd4-1
Nedd4a
Rpf1

Gene ID

17999

Organism

Mus musculus (house mouse)

External Links

GlyGen: P46935
PubChem: P46935
The O-GlcNAc Database: P46935
RaftProt: P46935
O-GlcNAcAtlas: P46935
Re-Glyco: P46935

Annotation

Keyword

3D-structure
Cell membrane
Cytoplasm
Isopeptide bond
Neurogenesis
Nucleus
Phosphoprotein
Reference proteome
Repeat
Transferase
Ubl conjugation
Ubl conjugation pathway

Gene Ontology (GO)

Displaying **all 8** entries
GO Term
glutamatergic synapse
postsynaptic cytosol
nucleus
cytoplasm
plasma membrane
membrane
cytosol
ubiquitin ligase complex

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 19 in total

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GO Term
negative regulation of transcription by RNA polymerase II
outflow tract morphogenesis
ubiquitin-dependent protein catabolic process
sodium ion transport
protein ubiquitination
positive regulation of protein catabolic process
endocardial cushion development
protein monoubiquitination
negative regulation of vascular endothelial growth factor receptor signaling pathway
regulation of dendrite morphogenesis

Displaying **all 6** entries
GO Term
phosphoserine residue binding
ubiquitin protein ligase activity
sodium channel inhibitor activity
ionotropic glutamate receptor binding
proline-rich region binding
phosphothreonine residue binding

Annotation information from UniProt.

Sequence

MSSDMAADESEAPVLSEDEVWEFCLDKTEDGGGSPGSDVTDTCEPPCGCWELNPNSLEEEHVLFTADPYLELHNDDTRVVRVKVIAGIGLAKKDILGASDPYVRVTLYDPMSGILTSVQTKTIKKSLNPKWNEEILFRVLPQRHRILFEVFDENRLTRDDFLGQVDVPLYPLPTENPRMERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKNGSEDENADQAEELEPGWVVLDQPDAATHLPHPPEPSPLPPGWEERQDVLGRTYYVNHESRRTQWKRPSPDDDLTDEDNDDMQLQAQRAFTTRRQISEDVDGPDNRESPENWEIVREDENTEYSGQAVQSPPSGHIDVQTHLAEEFNTRLAVCGNPATSQPVTSSNHSSRGGSLQTCIFEEQPTLPVLLPTSSGLPPGWEEKQDDRGRSYYVDHNSKTTTWSKPTMQDDPRSKIPAHLRGKTDSNDLGPLPPGWEERTHTDGRVFFINHNIKKTQWEDPRLQNVAITGPAVPYSRDYKRKYEFFRRKLKKQTDIPNKFEMKLRRANILEDSYRRIMGVKRADLLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEYYSSLRWILENDPTELDLRFIIDEELFGQTHQHELKTGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSMNHQVIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPDKLPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQGFDGVD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	GlyTouCan ID	Source
370	G49108TO	The O-GlcNAc Database
371	G49108TO	GlyGen The O-GlcNAc Database
375	G49108TO	GlyGen The O-GlcNAc Database
376	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Antigen processing: Ubiquitination & Proteasome degradation	Mus musculus
Downregulation of ERBB4 signaling	Mus musculus
ISG15 antiviral mechanism	Mus musculus
Regulation of PTEN localization	Mus musculus
Regulation of PTEN stability and activity	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

Annotation

International Collaboration

Acknowledgements