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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Protransforming growth factor alpha
Summary
- UniProt ID
- P48030
- Gene Symbol
-
- Tgfa
- Organism
- Mus musculus (house mouse)
External Links
- PubChem
- P48030
Annotation
- Keyword
-
- Cell membrane
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Growth factor
- Mitogen
- Palmitate
- Reference proteome
- Secreted
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| positive regulation of epithelial cell proliferation |
| positive regulation of cell division |
| ERBB2-EGFR signaling pathway |
| GO Term |
|---|
| cell surface |
| basolateral plasma membrane |
| perinuclear region of cytoplasm |
| extracellular space |
| cytoplasmic vesicle |
Sequence
MVPATGQLALLALGILLAVCQALENSTSPLSDSPVAAAVVSHFNKCPDSHTQYCFHGTCRFLVQEEKPACVCHSGYVGVRCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQLRKHCEWCRALVCRHEKPSALLKGRTACCHSETVV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 25 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| COPII-mediated vesicle transport | Mus musculus |
| Cargo concentration in the ER | Mus musculus |
| Cargo recognition for clathrin-mediated endocytosis | Mus musculus |
| Clathrin-mediated endocytosis | Mus musculus |
| EGFR downregulation | Mus musculus |
| EGFR interacts with phospholipase C-gamma | Mus musculus |
| Extra-nuclear estrogen signaling | Mus musculus |
| GAB1 signalosome | Mus musculus |
| GRB2 events in EGFR signaling | Mus musculus |
| PI3K/AKT Signaling | Mus musculus |
