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Protein ERGIC-53

Summary

UniProt ID

P49257

Gene Symbol

LMAN1
ERGIC53
F5F8D

Organism

Homo sapiens (human)

External Links

GlyGen: P49257
PubChem: P49257
The O-GlcNAc Database: P49257
RaftProt: P49257
O-GlcNAcAtlas: P49257

Annotation

Keyword

3D-structure
Direct protein sequencing
Disulfide bond
ER-Golgi transport
Endoplasmic reticulum
Golgi apparatus
Lectin
Metal-binding
Phosphoprotein
Protein transport
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 8** entries
GO Term
Golgi organization
blood coagulation
protein transport
positive regulation of organelle organization
protein folding
endoplasmic reticulum to Golgi vesicle-mediated transport
endoplasmic reticulum organization
negative regulation of protein targeting to mitochondrion

Displaying entries **1 - 10** of 11 in total

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GO Term
Golgi membrane
membrane
sarcomere
collagen-containing extracellular matrix
extracellular exosome
endoplasmic reticulum
endoplasmic reticulum membrane
endoplasmic reticulum-Golgi intermediate compartment
ER to Golgi transport vesicle membrane
COPII-coated ER to Golgi transport vesicle

Displaying **all 3** entries
GO Term
metal ion binding
unfolded protein binding
mannose binding

Annotation information from UniProt.

Sequence

MAGSRQRGLRARVRPLFCALLLSLGRFVRGDGVGGDPAVALPHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLTEPGKEPPTPDKEISEKEKEKYQEEFEHFQQELDKKKEEFQKGHPDLQGQPAEEIFESVGDRELRQVFEGQNRIHLEIKQLNRQLDMILDEQRRYVSSLTEEISKRGAGMPGQHGQITQQELDTVVKTQHEILRQVNEMKNSMSETVRLVSGMQHPGSAGGVYETTQHFIDIKEHLHIVKRDIDNLVQRNMPSNEKPKCPELPPFPSCLSTVHFIIFVVVQTVLFIGYIMYRSQQEAAAKKFF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	GlyTouCan ID	Source
4	G49108TO	GlyGen The O-GlcNAc Database
266	G57321FI	GlyGen
276	G57321FI	GlyGen
364	G49108TO	GlyGen
365	G49108TO	GlyGen The O-GlcNAc Database
374	G57321FI	GlyGen
385	G57321FI	GlyGen
416	G57321FI	GlyGen
417	G57321FI	GlyGen
425	G53434XO G43417UB G29068FM G57321FI	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
COPII-mediated vesicle transport	Homo sapiens
Cargo concentration in the ER	Homo sapiens
RAC2 GTPase cycle	Homo sapiens
RAC3 GTPase cycle	Homo sapiens
RHOA GTPase cycle	Homo sapiens
RHOC GTPase cycle	Homo sapiens
RHOD GTPase cycle	Homo sapiens
RHOG GTPase cycle	Homo sapiens
Transport to the Golgi and subsequent modification	Homo sapiens

Human Protein Atlas

ENSG00000074695

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying entries **1 - 10** of 28 in total

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DO ID	Disease Name	Source
DOID:0111401	congenital dyserythropoietic anemia type II	DisGeNET
DOID:11249	vitamin K deficiency bleeding	DisGeNET
DOID:1205	allergic disease	DisGeNET
DOID:12134	factor VIII deficiency	DisGeNET DisGeNET
DOID:12365	malaria	DisGeNET
DOID:1247	blood coagulation disease	DisGeNET DisGeNET
DOID:1338	congenital dyserythropoietic anemia	DisGeNET
DOID:13481	thanatophoric dysplasia	DisGeNET
DOID:13739	nutmeg liver	DisGeNET
DOID:162	cancer	DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Annotation

International Collaboration

Acknowledgements