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Natural resistance-associated macrophage protein 1

Summary

UniProt ID

P49279

Gene Symbol

SLC11A1
LSH
NRAMP
NRAMP1

Organism

Homo sapiens (human)

External Links

PubChem: P49279
The Human Metabolome Database: HMDBP08680

Annotation

Keyword

Alternative splicing
Endosome
Glycoprotein
Iron transport
Lysosome
Proteomics identification
Reference proteome
Transmembrane helix

Gene Ontology (GO)

Displaying entries **21 - 30** of 38 in total

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GO Term
establishment of localization in cell
positive regulation of dendritic cell antigen processing and presentation
positive regulation of T-helper 1 type immune response
response to type II interferon
MHC class II biosynthetic process
antigen processing and presentation of peptide antigen
cellular detoxification of cadmium ion
iron ion transport
manganese ion transport
intracellular iron ion homeostasis

Displaying **all 9** entries
GO Term
lysosome
plasma membrane
ficolin-1-rich granule membrane
lysosomal membrane
endosome membrane
phagocytic vesicle membrane
late endosome membrane
late endosome
tertiary granule membrane

Displaying **all 6** entries
GO Term
transition metal ion transmembrane transporter activity
metal cation:proton antiporter activity
manganese ion transmembrane transporter activity
cadmium ion transmembrane transporter activity
protein homodimerization activity
iron ion transmembrane transporter activity

Annotation information from UniProt.

Sequence

MTGDKGPQRLSGSSYGSISSPTSPTSPGPQQAPPRETYLSEKIPIPDTKPGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAFNLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVARPEQGALLRGLFLPSCPGCGHPELLQAVGIVGAIIMPHNIYLHSALVKSREIDRARRADIREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIFPMNNATVAVDIYQGGVILGCLFGPAALYIWAIGLLAAGQSSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPTLMQEFANGLLNKVVTSSIMVLVCAINLYFVVSYLPSLPHPAYFGLAALLAAAYLGLSTYLVWTCCLAHGATFLAHSSHHHFLYGLLEEDQKGETSG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
324	N-linked (GlcNAc...) asparagine			UniProt
338	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Ion influx/efflux at host-pathogen interface	Homo sapiens
Metal ion SLC transporters	Homo sapiens
Neutrophil degranulation	Homo sapiens
ROS and RNS production in phagocytes	Homo sapiens