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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
DNA primase large subunit
Summary
- UniProt ID
- P49643
- Gene Symbol
-
- PRIM2
- PRIM2A
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P49643
- PubChem
- P49643
- The Human Metabolome Database
- HMDBP11900
- The O-GlcNAc Database
- P49643
Annotation
- Keyword
-
- 3D-structure
- 4Fe-4S
- Alternative splicing
- DNA replication
- DNA-binding
- Phosphoprotein
- Primosome
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| DNA replication, synthesis of RNA primer |
| DNA replication initiation |
| positive regulation of DNA primase activity |
| GO Term |
|---|
| nucleoplasm |
| alpha DNA polymerase:primase complex |
| GO Term |
|---|
| DNA binding |
| metal ion binding |
| 4 iron, 4 sulfur cluster binding |
| DNA/RNA hybrid binding |
Sequence
MEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQSKLESELRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIVASSPSLSGLKLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALALTARSLPAVQSDERLQPLLNHLSHSYTGQDYSTQGNVGKISLDQIDLLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLTLEQALQFWKQEFIKGKMDPDKFDKGYSYNIRHSFGKEGKRTDYTPFSCLKIILSNPPSQGDYHGCPFRHSDPELLKQKLQSYKISPGGISQILDLVKGTHYQVACQKYFEMIHNVDDCGFSLNHPNQFFCESQRILNGGKDIKKEPIQPETPQPKPSVQKTKDASSALASLNSSLEMDMEGLEDYFSEDS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of the pre-replicative complex | Homo sapiens |
| DNA replication initiation | Homo sapiens |
| Defective pyroptosis | Homo sapiens |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | Homo sapiens |
| Polymerase switching | Homo sapiens |
| Polymerase switching on the C-strand of the telomere | Homo sapiens |
| Processive synthesis on the lagging strand | Homo sapiens |
| Removal of the Flap Intermediate | Homo sapiens |
| Telomere C-strand synthesis initiation | Homo sapiens |
