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Glypican-3

Summary
UniProt ID
P51654
Gene Symbol
  • GPC3
  • OCI5
Organism
Homo sapiens (human)
External Links
GlycoProtDB
GPDB0011721
GlyGen
P51654
PubChem
P51654
The O-GlcNAc Database
P51654
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • GPI-anchor
  • Heparan sulfate
  • Phosphoprotein
  • Protease inhibitor
  • Pyrrolidone carboxylic acid
  • Reference proteome
  • Signal
Gene Ontology (GO)
Displaying 1 entry
GO Term
peptidyl-dipeptidase inhibitor activity
Annotation information from UniProt.
Sequence
MAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLAELAYDLDVDDAPGNSQQATPKDNEISTFHNLGNVHSPLKLLTSMAISVVCFFFLVH
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 7 entries
Position Description PubMed ID GlyTouCan ID Source
124 N-linked (GlcNAc...) asparagine
241 N-linked (GlcNAc...) asparagine
359
418 N-linked (GlcNAc...) asparagine
495 O-linked (Xyl...) (glycosaminoglycan) serine
509 O-linked (Xyl...) (glycosaminoglycan) serine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 14 in total
Pathway Name Organism
A tetrasaccharide linker sequence is required for GAG synthesis Homo sapiens
Attachment and Entry Homo sapiens
Defective B3GALT6 causes EDSP2 and SEMDJL1 Homo sapiens
Defective B3GAT3 causes JDSSDHD Homo sapiens
Defective B4GALT7 causes EDS, progeroid type Homo sapiens
Defective EXT1 causes exostoses 1, TRPS2 and CHDS Homo sapiens
Defective EXT2 causes exostoses 2 Homo sapiens
HS-GAG biosynthesis Homo sapiens
HS-GAG degradation Homo sapiens
Post-translational protein phosphorylation Homo sapiens
Disease
Displaying entries 171 - 180 of 220 in total
DO ID Disease Name Source
DOID:4866 salivary gland adenoid cystic carcinoma
DOID:4896 bile duct adenocarcinoma
DOID:4897 bile duct carcinoma
DOID:4903 granular cell carcinoma
DOID:4905 pancreatic carcinoma
DOID:4928 intrahepatic cholangiocarcinoma
DOID:4929 tubular adenocarcinoma
DOID:4947 cholangiocarcinoma
DOID:4948 gallbladder carcinoma
DOID:5082 liver cirrhosis
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024