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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Peroxisomal multifunctional enzyme type 2
Summary
- UniProt ID
- P51659
- Gene Symbol
-
- HSD17B4
- EDH17B4
- SDR8C1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Deafness
- Direct protein sequencing
- Disease variant
- Fatty acid metabolism
- Isomerase
- Lyase
- NAD
- Oxidoreductase
- Peroxisome
- Phosphoprotein
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| membrane |
| peroxisome |
| cytosol |
| peroxisomal membrane |
| peroxisomal matrix |
Sequence
MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLSKIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKDLKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAKL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 281 |
|
|||
| 354 |
|
|||
| 474 |
|
|||
| 475 |
|
|||
| 665 |
|
G41840AI
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Beta-oxidation of pristanoyl-CoA | Homo sapiens |
| Beta-oxidation of very long chain fatty acids | Homo sapiens |
| Peroxisomal protein import | Homo sapiens |
| Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | Homo sapiens |
| TYSND1 cleaves peroxisomal proteins | Homo sapiens |
| alpha-linolenic acid (ALA) metabolism | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1443 | cerebral degeneration | |
| DOID:14447 | gonadal dysgenesis | |
| DOID:14525 | Reye syndrome | |
| DOID:14693 | Clouston syndrome | |
| DOID:14723 | beta-ketothiolase deficiency | |
| DOID:1520 | colon carcinoma | |
| DOID:1612 | breast cancer | |
| DOID:162 | cancer | |
| DOID:1826 | epilepsy | |
| DOID:1837 | diabetic ketoacidosis |
