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Pyruvate kinase PKM

Summary

UniProt ID

P52480

Gene Symbol

Pk3
Pkm
Pkm2
Pykm

Gene ID

18746

Organism

Mus musculus (house mouse)

External Links

GlyGen: P52480
PubChem: P52480
The Human Metabolome Database: HMDBP13273
RaftProt: P52480
O-GlcNAcAtlas: P52480
Re-Glyco: P52480

Annotation

Keyword

ATP-binding
Acetylation
Allosteric enzyme
Alternative splicing
Cytoplasm
Direct protein sequencing
Glycolysis
Hydroxylation
Isopeptide bond
Kinase
Magnesium
Metal-binding
Methylation
Nucleus
Phosphoprotein
Potassium
Pyruvate
Reference proteome
S-nitrosylation
Translation regulation
Ubl conjugation

Gene Ontology (GO)

Displaying **all 8** entries
GO Term
nucleus
mitochondrion
cilium
myelin sheath
collagen-containing extracellular matrix
rough endoplasmic reticulum
cytosol
photoreceptor inner segment

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 6** entries
GO Term
canonical glycolysis
positive regulation of sprouting angiogenesis
positive regulation of cytoplasmic translation
glycolytic process
programmed cell death
positive regulation of transcription by RNA polymerase II

Displaying entries **1 - 10** of 11 in total

1

2

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GO Term
magnesium ion binding
mRNA binding
protein tyrosine kinase activity
pyruvate kinase activity
ATP binding
potassium ion binding
protein homodimerization activity
histone H2AXY142 kinase activity
transcription coactivator activity
histone H3Y41 kinase activity

Annotation information from UniProt.

Sequence

MPKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLNAWAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites