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Amyloid-beta precursor protein

Summary

UniProt ID

P53601

Gene Symbol

APP
A4
AD1

Organism

Macaca fascicularis (crab-eating macaque)

External Links

PubChem: P53601

Annotation

Keyword

Alternative splicing
Amyloid
Apoptosis
Cell adhesion
Cell membrane
Cell projection
Coated pit
Copper
Cytoplasm
Cytoplasmic vesicle
Disulfide bond
Endocytosis
Endoplasmic reticulum
Endosome
Golgi apparatus
Heparin-binding
Iron
Isopeptide bond
Metal-binding
Notch signaling pathway
Nucleus
Phosphoprotein
Proteoglycan
Reference proteome
Secreted
Serine protease inhibitor
Signal
Sulfation
Transmembrane helix
Ubl conjugation
Zinc

Gene Ontology (GO)

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GO Term
negative regulation of neuron differentiation
positive regulation of mitotic cell cycle
regulation of synapse structure or activity
positive regulation of calcium-mediated signaling
neuromuscular process controlling balance
neuron apoptotic process
neuron cellular homeostasis
modulation of excitatory postsynaptic potential
positive regulation of T cell migration
regulation of presynapse assembly

Displaying entries **1 - 10** of 29 in total

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GO Term
receptor complex
presynaptic active zone
spindle midzone
growth cone
apical part of cell
dendritic shaft
perikaryon
membrane raft
endoplasmic reticulum
nuclear envelope lumen

Displaying **all 9** entries
GO Term
PTB domain binding
identical protein binding
serine-type endopeptidase inhibitor activity
receptor ligand activity
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA binding
heparin binding
enzyme binding
transition metal ion binding

Annotation information from UniProt.

Sequence

MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSVMSQSLRKTTREPLTRDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites