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Amyloid-beta precursor protein

Summary

UniProt ID

P53601

Gene Symbol

A4
AD1
APP
QccE-15949

Gene ID

101926433

Organism

Macaca fascicularis (crab-eating macaque)

External Links

PubChem: P53601
Re-Glyco: P53601

Annotation

Keyword

Alternative splicing
Amyloid
Apoptosis
Cell adhesion
Cell membrane
Cell projection
Coated pit
Copper
Cytoplasm
Cytoplasmic vesicle
Disulfide bond
Endocytosis
Endoplasmic reticulum
Endosome
Golgi apparatus
Heparin-binding
Iron
Isopeptide bond
Metal-binding
Notch signaling pathway
Nucleus
Phosphoprotein
Proteoglycan
Reference proteome
Secreted
Serine protease inhibitor
Signal
Sulfation
Transmembrane helix
Ubl conjugation
Zinc

Gene Ontology (GO)

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GO Term
presynaptic active zone
recycling endosome
smooth endoplasmic reticulum
spindle midzone
extracellular space
cytoplasm
plasma membrane
cell-cell junction
membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
gene expression
regulation of translation
positive regulation of calcium-mediated signaling
neuron apoptotic process
positive regulation of ERK1 and ERK2 cascade
positive regulation of non-canonical NF-kappaB signal transduction
cellular response to amyloid-beta
amyloid fibril formation
G2/M transition of mitotic cell cycle
suckling behavior

Displaying **all 9** entries
GO Term
heparin binding
PTB domain binding
protein serine/threonine kinase binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA binding
serine-type endopeptidase inhibitor activity
identical protein binding
transition metal ion binding
receptor ligand activity

Annotation information from UniProt.

Sequence

MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSVMSQSLRKTTREPLTRDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites