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MIRAGE
Pro-neuregulin-2, membrane-bound isoform
Summary
- UniProt ID
- P56974
- Gene Symbol
-
- Nrg2
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Alternative splicing
- Cell membrane
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Growth factor
- Immunoglobulin domain
- Reference proteome
- Secreted
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular space |
| plasma membrane |
| GO Term |
|---|
| cell surface receptor signaling pathway |
| nervous system development |
| ERBB4 signaling pathway |
| ERBB2-ERBB3 signaling pathway |
| ERBB4-ERBB4 signaling pathway |
| GO Term |
|---|
| ErbB-4 class receptor binding |
| growth factor activity |
| receptor ligand activity |
Sequence
MRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEGKVQGLAPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVGSCAPLERNQRYIFFLEPTEQPLVFKTAFAPVDPNGKNIKKEVGKILCTDCATRPKLKKMKSQTGEVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVRVEDAGEYVCEAENILGKDTVRGRLHVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRRQMHHHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRREAETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYSQEERRRAAMPPYHDSIDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGSGPGADMQRSYDSYYYPAAGPGPRRSACALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRTRGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGCGSASASDDDADDADGALAAESTPFLGLRAAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPTRAKQDSGPL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 55 | N-linked (GlcNAc...) asparagine | |||
| 186 | N-linked (GlcNAc...) asparagine | |||
| 254 | N-linked (GlcNAc...) asparagine | |||
| 296 | N-linked (GlcNAc...) asparagine |
|
G86182NS
G42124LM
G05724UK
G39446WN
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Downregulation of ERBB2 signaling | Mus musculus |
| Downregulation of ERBB2:ERBB3 signaling | Mus musculus |
| ERBB2 Activates PTK6 Signaling | Mus musculus |
| ERBB2 Regulates Cell Motility | Mus musculus |
| GRB2 events in ERBB2 signaling | Mus musculus |
| GRB7 events in ERBB2 signaling | Mus musculus |
| PI3K events in ERBB2 signaling | Mus musculus |
| PI3K events in ERBB4 signaling | Mus musculus |
| PI3K/AKT Signaling | Mus musculus |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Mus musculus |
