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Toll-like receptor 7

Summary

UniProt ID

P58681

Gene Symbol

Tlr7

Gene ID

170743

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003723
PubChem: P58681
RaftProt: P58681
Re-Glyco: P58681

Annotation

Keyword

Cytoplasmic vesicle
Endoplasmic reticulum
Endosome
Glycoprotein
Inflammatory response
Innate immunity
Leucine-rich repeat
Lysosome
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 8** entries
GO Term
endosome
endoplasmic reticulum
endoplasmic reticulum membrane
endosome membrane
early phagosome
lysosome
plasma membrane
receptor complex

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 21 in total

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GO Term
toll-like receptor 7 signaling pathway
response to cGMP
toll-like receptor 8 signaling pathway
positive regulation of transcription by RNA polymerase II
MAPK cascade
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of macrophage cytokine production

Displaying **all 3** entries
GO Term
siRNA binding
double-stranded RNA binding
single-stranded RNA binding

Annotation information from UniProt.

Sequence

MVFSMWTRKRQILIFLNMLLVSRVFGFRWFPKTLPCEVKVNIPEAHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHIPSISPDSFRRLNHLEEIDLRCNCVPVLLGSKANVCTKRLQIRPGSFSGLSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANNIFSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIEEAKFLHFLPNLVELDFSFNYELQVYHASITLPHSLSSLENLKILRVKGYVFKELKNSSLSVLHKLPRLEVLDLGTNFIKIADLNIFKHFENLKLIDLSVNKISPSEESREVGFCPNAQTSVDRHGPQVLEALHYFRYDEYARSCRFKNKEPPSFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAFEELQSLEVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWRAGDNRYLDFFKNLFNLEVLDISRNSLNSLPPEVFEGMPPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMVVMTTSHLFFWDMWYIYYFWKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEWVLQELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYLSHQRLLDEKVDVIILIFLEKPLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCLKNALTTDNHVAYSQMFKETV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 12 in total

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Position	Description	Source
66	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt
69	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt
167	N-linked (GlcNAc...) asparagine	UniProt
190	N-linked (GlcNAc...) asparagine	UniProt
215	N-linked (GlcNAc...) asparagine	UniProt
387	N-linked (GlcNAc...) asparagine	UniProt
524	N-linked (GlcNAc...) asparagine	UniProt
535	N-linked (GlcNAc...) asparagine	UniProt
591	N-linked (GlcNAc...) asparagine	UniProt
680	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Regulation of TLR by endogenous ligand	Mus musculus
Toll Like Receptor 7/8 (TLR7/8) Cascade	Mus musculus
Trafficking and processing of endosomal TLR	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

International Collaboration

Acknowledgements