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Major prion protein

Summary

UniProt ID

P61768

Gene Symbol

PRNP
PRP

Organism

Pan troglodytes (chimpanzee)

External Links

PubChem: P61768

Annotation

Keyword

Cell membrane
Copper
Disulfide bond
GPI-anchor
Golgi apparatus
Metal-binding
Prion
Reference proteome
Repeat
Signal
Zinc

Gene Ontology (GO)

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GO Term
negative regulation of type II interferon production
negative regulation of apoptotic process
negative regulation of calcineurin-NFAT signaling cascade
protein destabilization
negative regulation of interleukin-17 production
negative regulation of T cell receptor signaling pathway
protein homooligomerization
cellular response to xenobiotic stimulus
positive regulation of protein targeting to membrane
regulation of potassium ion transmembrane transport

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GO Term
cell surface
dendrite
nuclear membrane
membrane raft
terminal bouton
endoplasmic reticulum
Golgi apparatus
cytosol
side of membrane
plasma membrane

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GO Term
signaling receptor activity
molecular function activator activity
cupric ion binding
amyloid-beta binding
protease binding
copper ion binding
glycosaminoglycan binding
microtubule binding
aspartic-type endopeptidase inhibitor activity
identical protein binding

Annotation information from UniProt.

Sequence

MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDQYSSQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites