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Major prion protein

Summary

UniProt ID

P61768

Gene Symbol

PRNP
PRP

Organism

Pan troglodytes (chimpanzee)

External Links

PubChem: P61768

Annotation

Keyword

Cell membrane
Copper
Disulfide bond
GPI-anchor
Golgi apparatus
Metal-binding
Prion
Reference proteome
Repeat
Signal
Zinc

Gene Ontology (GO)

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GO Term
cellular response to amyloid-beta
negative regulation of interleukin-2 production
negative regulation of activated T cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
cellular response to copper ion
regulation of glutamate receptor signaling pathway
neuron projection maintenance
negative regulation of type II interferon production
negative regulation of apoptotic process
negative regulation of calcineurin-NFAT signaling cascade

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GO Term
cell surface
dendrite
nuclear membrane
membrane raft
endoplasmic reticulum
Golgi apparatus
cytosol
side of membrane
plasma membrane
inclusion body

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GO Term
aspartic-type endopeptidase inhibitor activity
identical protein binding
protein-containing complex binding
molecular condensate scaffold activity
type 5 metabotropic glutamate receptor binding
cuprous ion binding
signaling receptor activity
molecular function activator activity
cupric ion binding
amyloid-beta binding

Annotation information from UniProt.

Sequence

MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDQYSSQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites