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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Glypican-5
Summary
- UniProt ID
- P78333
- Gene Symbol
-
- GPC5
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Cell membrane
- GPI-anchor
- Heparan sulfate
- Reference proteome
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| cell migration |
| regulation of protein localization to membrane |
| positive regulation of canonical Wnt signaling pathway |
| GO Term |
|---|
| extracellular region |
| plasma membrane |
| membrane |
| collagen-containing extracellular matrix |
| Golgi lumen |
| cell surface |
| side of membrane |
| lysosomal lumen |
Sequence
MDAQTWPVGFRCLLLLALVGSARSEGVQTCEEVRKLFQWRLLGAVRGLPDSPRAGPDLQVCISKKPTCCTRKMEERYQIAARQDMQQFLQTSSSTLKFLISRNAAAFQETLETLIKQAENYTSILFCSTYRNMALEAAASVQEFFTDVGLYLFGADVNPEEFVNRFFDSLFPLVYNHLINPGVTDSSLEYSECIRMARRDVSPFGNIPQRVMGQMGRSLLPSRTFLQALNLGIEVINTTDYLHFSKECSRALLKMQYCPHCQGLALTKPCMGYCLNVMRGCLAHMAELNPHWHAYIRSLEELSDAMHGTYDIGHVLLNFHLLVNDAVLQAHLNGQKLLEQVNRICGRPVRTPTQSPRCSFDQSKEKHGMKTTTRNSEETLANRRKEFINSLRLYRSFYGGLADQLCANELAAADGLPCWNGEDIVKSYTQRVVGNGIKAQSGNPEVKVKGIDPVINQIIDKLKHVVQLLQGRSPKPDKWELLQLGSGGGMVEQVSGDCDDEDGCGGSGSGEVKRTLKITDWMPDDMNFSDVKQIHQTDTGSTLDTTGAGCAVATESMTFTLISVVMLLPGIW
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 120 | N-linked (GlcNAc...) asparagine |
|
||
| 237 | N-linked (GlcNAc...) asparagine |
|
||
| 379 |
|
|||
| 441 | O-linked (Xyl...) (glycosaminoglycan) serine |
|
||
| 486 | O-linked (Xyl...) (glycosaminoglycan) serine |
|
||
| 495 | O-linked (Xyl...) (glycosaminoglycan) serine |
|
||
| 507 | O-linked (Xyl...) (glycosaminoglycan) serine |
|
||
| 509 | O-linked (Xyl...) (glycosaminoglycan) serine |
|
||
| 527 | N-linked (GlcNAc...) asparagine |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| A tetrasaccharide linker sequence is required for GAG synthesis | Homo sapiens |
| Attachment and Entry | Homo sapiens |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | Homo sapiens |
| Defective B3GAT3 causes JDSSDHD | Homo sapiens |
| Defective B4GALT7 causes EDS, progeroid type | Homo sapiens |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | Homo sapiens |
| Defective EXT2 causes exostoses 2 | Homo sapiens |
| HS-GAG biosynthesis | Homo sapiens |
| HS-GAG degradation | Homo sapiens |
| RSV-host interactions | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110270 | cataract 17 multiple types | |
| DOID:0110271 | cataract 23 | |
| DOID:0110272 | cataract 40 | |
| DOID:0111029 | hemochromatosis type 1 | |
| DOID:10283 | prostate cancer | |
| DOID:10286 | prostate carcinoma | |
| DOID:10588 | adrenoleukodystrophy | |
| DOID:10629 | microphthalmia | |
| DOID:1089 | tethered spinal cord syndrome | |
| DOID:10952 | nephritis |
