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Mothers against decapentaplegic homolog 4

Summary

UniProt ID

P97471

Gene Symbol

Smad4
Dpc4
Madh4

Organism

Mus musculus (house mouse)

External Links

GlyGen: P97471
PubChem: P97471
The Human Metabolome Database: HMDBP14461

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Reference proteome
Transcription regulation
Ubl conjugation
Zinc

Gene Ontology (GO)

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GO Term
positive regulation of cell proliferation involved in heart valve morphogenesis
mesendoderm development
sebaceous gland development
formation of anatomical boundary
regulation of hair follicle development
endocardial cell differentiation
female gonad morphogenesis
negative regulation of cardiac myofibril assembly
negative regulation of transcription by RNA polymerase II
osteoblast differentiation

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GO Term
cytosol
nucleoplasm
chromatin
nucleus
cytoplasm
protein-containing complex
transcription regulator complex
centrosome
activin responsive factor complex
heteromeric SMAD protein complex

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GO Term
RNA polymerase II transcription regulatory region sequence-specific DNA binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
transcription corepressor binding
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA binding
DNA-binding transcription factor activity
collagen binding
filamin binding
identical protein binding

Annotation information from UniProt.

Sequence

MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSMLVKDEYVHDFEGQPSLPTEGHSIQTIQHPPSNRASTETYSAPALLAPAESNATSTTNFPNIPVASTSQPASILAGSHSEGLLQIASGPQPGQQQNGFTAQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPVVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
3			G02815KT	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 10** entries
Pathway Name	Organism
Downregulation of SMAD2/3:SMAD4 transcriptional activity	Mus musculus
FOXO-mediated transcription of cell cycle genes	Mus musculus
RUNX2 regulates bone development	Mus musculus
RUNX3 regulates CDKN1A transcription	Mus musculus
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	Mus musculus
Signaling by Activin	Mus musculus
Signaling by BMP	Mus musculus
Signaling by NODAL	Mus musculus
TGF-beta receptor signaling activates SMADs	Mus musculus
Ub-specific processing proteases	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements