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Mothers against decapentaplegic homolog 4

Summary

UniProt ID

P97471

Gene Symbol

Smad4
Dpc4
Madh4

Organism

Mus musculus (house mouse)

External Links

GlyGen: P97471
PubChem: P97471
The Human Metabolome Database: HMDBP14461
The O-GlcNAc Database: P97471

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Reference proteome
Transcription regulation
Ubl conjugation
Zinc

Gene Ontology (GO)

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GO Term
positive regulation of DNA-templated transcription
intracellular iron ion homeostasis
spermatogenesis
single fertilization
gastrulation
endoderm development
mesoderm development
cell population proliferation
negative regulation of cell population proliferation
male gonad development

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GO Term
protein-containing complex
cytosol
nucleoplasm
transcription regulator complex
centrosome
RNA polymerase II transcription regulator complex
activin responsive factor complex
heteromeric SMAD protein complex
chromatin
nucleus

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GO Term
protein-containing complex binding
metal ion binding
sulfate binding
RNA polymerase II-specific DNA-binding transcription factor binding
filamin binding
identical protein binding
protein homodimerization activity
SMAD binding
RNA polymerase II transcription regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific

Annotation information from UniProt.

Sequence

MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSMLVKDEYVHDFEGQPSLPTEGHSIQTIQHPPSNRASTETYSAPALLAPAESNATSTTNFPNIPVASTSQPASILAGSHSEGLLQIASGPQPGQQQNGFTAQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPVVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
3			G02815KT	GlyGen
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 10** entries
Pathway Name	Organism
Downregulation of SMAD2/3:SMAD4 transcriptional activity	Mus musculus
FOXO-mediated transcription of cell cycle genes	Mus musculus
RUNX2 regulates bone development	Mus musculus
RUNX3 regulates CDKN1A transcription	Mus musculus
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	Mus musculus
Signaling by Activin	Mus musculus
Signaling by BMP	Mus musculus
Signaling by NODAL	Mus musculus
TGF-beta receptor signaling activates SMADs	Mus musculus
Ub-specific processing proteases	Mus musculus