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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Proheparin-binding EGF-like growth factor
Summary
- UniProt ID
- Q06186
- Gene Symbol
-
- Hbegf
- Dtr
- Hegfl
- Organism
- Mus musculus (house mouse)
External Links
- PubChem
- Q06186
Annotation
- Keyword
-
- Cell membrane
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Growth factor
- Heparin-binding
- Reference proteome
- Secreted
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| cell migration |
| positive regulation of cell growth |
| cell chemotaxis |
| positive regulation of wound healing |
| ERBB2-EGFR signaling pathway |
| ERBB2-ERBB4 signaling pathway |
| negative regulation of elastin biosynthetic process |
| GO Term |
|---|
| extracellular region |
| extracellular space |
| plasma membrane |
| cell surface |
Sequence
MKLLPSVMLKLFLAAVLSALVTGESLERLRRGLAAATSNPDPPTGSTNQLLPTGGDRAQGVQDLEGTDLNLFKVAFSSKPQGLATPSKERNGKKKKKGKGLGKKRDPCLRKYKDYCIHGECRYLQEFRTPSCKCLPGYHGHRCHGLTLPVENPLYTYDHTTVLAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDLESEEKVKLGVASSH
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 85 | O-linked (GalNAc...) threonine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cargo recognition for clathrin-mediated endocytosis | Mus musculus |
| Clathrin-mediated endocytosis | Mus musculus |
| Downregulation of ERBB2 signaling | Mus musculus |
| EGFR Transactivation by Gastrin | Mus musculus |
| EGFR downregulation | Mus musculus |
| EGFR interacts with phospholipase C-gamma | Mus musculus |
| ERBB2 Activates PTK6 Signaling | Mus musculus |
| ERBB2 Regulates Cell Motility | Mus musculus |
| Extra-nuclear estrogen signaling | Mus musculus |
| GAB1 signalosome | Mus musculus |
