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Repository for lectin-assisted multimodality data
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MIRAGE
Mothers against decapentaplegic homolog 4
Summary
- UniProt ID
- Q13485
- Gene Symbol
-
- DPC4
- MADH4
- SMAD4
- Gene ID
- 4089
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Cytoplasm
- DNA-binding
- Disease variant
- Isopeptide bond
- Metal-binding
- Nucleus
- Phosphoprotein
- Reference proteome
- Transcription regulation
- Ubl conjugation
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| nucleoplasm |
| cytosol |
| transcription regulator complex |
| centrosome |
| activin responsive factor complex |
| heteromeric SMAD protein complex |
| SMAD protein complex |
| chromatin |
| nucleus |
| cytoplasm |
Sequence
MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGHSIQTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGLLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 42 |
|
|||
| 59 |
|
|||
| 62 |
|
|||
| 63 |
|
|||
| 69 |
|
|||
| 206 |
|
|||
| 209 |
|
|||
| 211 |
|
|||
| 221 |
|
|||
| 223 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cardiogenesis | Homo sapiens |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | Homo sapiens |
| FOXO-mediated transcription of cell cycle genes | Homo sapiens |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | Homo sapiens |
| Formation of definitive endoderm | Homo sapiens |
| Primitive streak formation | Homo sapiens |
| RUNX2 regulates bone development | Homo sapiens |
| RUNX3 regulates BCL2L11 (BIM) transcription | Homo sapiens |
| RUNX3 regulates CDKN1A transcription | Homo sapiens |
| SARS-CoV-1 targets host intracellular signalling and regulatory pathways | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050787 | juvenile polyposis syndrome | |
| DOID:0111543 | juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome | |
| DOID:1270 | hereditary hemorrhagic telangiectasia | |
| DOID:1793 | pancreatic cancer | |
| DOID:2394 | ovarian cancer | |
| DOID:2871 | endometrial carcinoma | |
| DOID:3119 | gastrointestinal system cancer | |
| DOID:3883 | Lynch syndrome | |
| DOID:4440 | seminoma | |
| DOID:520 | aortic disease |
