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Transcription factor HES-1

Summary

UniProt ID

Q14469

Gene Symbol

HES1
BHLHB39
HL
HRY

Organism

Homo sapiens (human)

External Links

GlyGen: Q14469
PubChem: Q14469
The O-GlcNAc Database: Q14469
O-GlcNAcAtlas: Q14469

Annotation

Keyword

3D-structure
DNA-binding
Nucleus
Reference proteome
Repressor
Transcription regulation
Ubl conjugation

Gene Ontology (GO)

Displaying entries **91 - 94** of 94 in total

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GO Term
cellular response to interleukin-1
negative regulation of calcium ion import
response to thyroid hormone
neuronal stem cell population maintenance

Displaying **all 5** entries
GO Term
nuclear matrix
chromatin
nucleus
cytoplasm
nucleoplasm

Displaying entries **1 - 10** of 15 in total

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GO Term
DNA binding
chromatin binding
JUN kinase binding
histone deacetylase binding
E-box binding
N-box binding
RNA polymerase II-specific DNA-binding transcription factor binding
protein-folding chaperone binding
protein homodimerization activity
HLH domain binding

Annotation information from UniProt.

Sequence

MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRPWRN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
55			G49108TO	GlyGen The O-GlcNAc Database
84			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Homo sapiens
Constitutive Signaling by NOTCH1 PEST Domain Mutants	Homo sapiens
NOTCH1 Intracellular Domain Regulates Transcription	Homo sapiens
NOTCH2 intracellular domain regulates transcription	Homo sapiens
NOTCH3 Intracellular Domain Regulates Transcription	Homo sapiens
NOTCH4 Intracellular Domain Regulates Transcription	Homo sapiens
RUNX2 regulates osteoblast differentiation	Homo sapiens
RUNX3 regulates NOTCH signaling	Homo sapiens
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	Homo sapiens