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MIRAGE
Toll-like receptor 1

Summary
UniProt ID
Q15399
Gene Symbol
  • KIAA0012
  • TLR1
Gene ID
7096
Organism
Homo sapiens (human)
GlyGen
Q15399
PubChem
Q15399
The Human Metabolome Database
HMDBP12415
Re-Glyco
Q15399
Annotation
Keyword
  • 3D-structure
  • Cell membrane
  • Cytoplasmic vesicle
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Golgi apparatus
  • Inflammatory response
  • Innate immunity
  • Leucine-rich repeat
  • NAD
  • Receptor
  • Reference proteome
  • Repeat
  • Signal
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 7 entries
GO Term
phagocytic vesicle membrane
Toll-like receptor 1-Toll-like receptor 2 protein complex
plasma membrane
membrane
receptor complex
Golgi apparatus
membrane raft
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MTSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLTEQAKK
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 7 entries
Position Description PubMed ID GlyTouCan ID Source
51 N-linked (GlcNAc...) asparagine
137 N-linked (GlcNAc...) asparagine
163 N-linked (GlcNAc...) asparagine
248
330 N-linked (GlcNAc...) asparagine
429 N-linked (GlcNAc...) asparagine
578 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 8 entries
Pathway Name Organism
Beta defensins Homo sapiens
ER-Phagosome pathway Homo sapiens
IRAK4 deficiency (TLR2/4) Homo sapiens
MyD88 deficiency (TLR2/4) Homo sapiens
MyD88:MAL(TIRAP) cascade initiated on plasma membrane Homo sapiens
Regulation of TLR by endogenous ligand Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses Homo sapiens
Toll Like Receptor TLR1:TLR2 Cascade Homo sapiens
Disease
Displaying all 6 entries
DO ID Disease Name Source
DOID:1024 leprosy
DOID:11400 pyelonephritis
DOID:13564 aspergillosis
DOID:2841 asthma
DOID:2986 IgA glomerulonephritis
DOID:399 tuberculosis
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025