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MIRAGE
Vesicular acetylcholine transporter

Summary
UniProt ID
Q16572
Gene Symbol
  • SLC18A3
  • VACHT
Gene ID
6572
Organism
Homo sapiens (human)
PubChem
Q16572
The Human Metabolome Database
HMDBP11999
Re-Glyco
Q16572
Annotation
Keyword
  • Congenital myasthenic syndrome
  • Cytoplasmic vesicle
  • Disease variant
  • Glycoprotein
  • Neurotransmitter transport
  • Reference proteome
  • Synapse
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 7 entries
GO Term
plasma membrane
AP-1 adaptor complex
AP-2 adaptor complex
synaptic vesicle membrane
terminal bouton
clathrin-coated endocytic vesicle membrane
clathrin-sculpted acetylcholine transport vesicle membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MESAEPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGGEGPTRTPEVWEPTLPLPTPANASAYTANTSASPTAAWPAGSALRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGASSCIVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLRERPVSGQDGEPRSPPGPFDACEDDYNYYYTRS
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 2 entries
Position Description PubMed ID GlyTouCan ID Source
89 N-linked (GlcNAc...) asparagine
96 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 3 entries
Pathway Name Organism
Acetylcholine Neurotransmitter Release Cycle Homo sapiens
Cargo recognition for clathrin-mediated endocytosis Homo sapiens
Clathrin-mediated endocytosis Homo sapiens
Disease
Displaying 1 entry
DO ID Disease Name Source
DOID:0110672 congenital myasthenic syndrome 21
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025