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Histone-lysine N-methyltransferase EZH2
Summary
- UniProt ID
- Q61188
- Gene Symbol
-
- Ezh2
- Enx1h
- Gene ID
- 14056
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Biological rhythms
- Chromatin regulator
- Chromosome
- Glycoprotein
- Isopeptide bond
- Methyltransferase
- Nucleus
- Phosphoprotein
- Reference proteome
- Repressor
- S-adenosyl-L-methionine
- Transcription regulation
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| nucleoplasm |
| nucleus |
| synapse |
| chromosome, telomeric region |
| chromatin silencing complex |
| ESC/E(Z) complex |
| pronucleus |
| pericentric heterochromatin |
Sequence
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPDEREEKQKDLEDNRDDKETCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Oxidative Stress Induced Senescence | Mus musculus |
| PKMTs methylate histone lysines | Mus musculus |
| PRC2 methylates histones and DNA | Mus musculus |
| Transcriptional Regulation by E2F6 | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:14731 | Weaver syndrome | |
| DOID:707 | B-cell lymphoma | |
| DOID:9952 | acute lymphoblastic leukemia |
