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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Summary

UniProt ID

Q8BTI9

Gene Symbol

Pik3cb

Gene ID

74769

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q8BTI9
PubChem: Q8BTI9
O-GlcNAcAtlas: Q8BTI9
Re-Glyco: Q8BTI9

Annotation

Keyword

3D-structure
ATP-binding
Autophagy
Cell adhesion
Cytoplasm
Endocytosis
Kinase
Lipid metabolism
Nucleus
Phosphoprotein
Reference proteome

Gene Ontology (GO)

Displaying **all 6** entries
GO Term
phosphatidylinositol 3-kinase complex, class IA
nucleoplasm
cytosol
midbody
nucleus
nucleolus

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
negative regulation of vascular endothelial growth factor signaling pathway
endothelial cell proliferation
sphingosine-1-phosphate receptor signaling pathway
positive regulation of endothelial cell migration
positive regulation of neutrophil apoptotic process
negative regulation of MAPK cascade
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
negative regulation of sprouting angiogenesis
angiogenesis involved in wound healing
intracellular calcium ion homeostasis

Displaying **all 6** entries
GO Term
protein serine kinase activity
1-phosphatidylinositol-3-kinase activity
insulin receptor substrate binding
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
ATP binding
kinase activity

Annotation information from UniProt.

Sequence

MPPAMADNLDIWAVDSQIASDGAISVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPAEKLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEAKIQSLVGLSWIDWLKHTYPPEHEPSVLENLEDKLYGGKLVVAVHFENSQDVFSFQVSPNLNPIKINELAIQKRLTIRGKEDEASPCDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRVISHIWDNNNPFQITLVKGNKLNTEETVKVHVRAGLFHGTELLCKTVVSSEISGKNDHIWNEQLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDELEEMLNPMGTVQTNPYAENATALHITFPENKKQPCYYPPFDKIIEKAAELASGDSANVSSRGGKKFLAVLKEILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALDNRRIGQFLFWHLRSEVHTPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLSRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYSSRAFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
715			G49108TO	GlyGen
718			G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
DAP12 signaling	Mus musculus
Downstream TCR signaling	Mus musculus
Downstream signal transduction	Mus musculus
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	Mus musculus
GPVI-mediated activation cascade	Mus musculus
IRS-mediated signalling	Mus musculus
Interleukin receptor SHC signaling	Mus musculus
Interleukin-3, Interleukin-5 and GM-CSF signaling	Mus musculus
PI3K Cascade	Mus musculus
PI3K/AKT Signaling	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements