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NAD-dependent protein deacetylase sirtuin-2

Summary

UniProt ID

Q8VDQ8

Gene Symbol

Sir2l2
Sirt2

Gene ID

64383

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q8VDQ8
PubChem: Q8VDQ8
The O-GlcNAc Database: Q8VDQ8
O-GlcNAcAtlas: Q8VDQ8
Re-Glyco: Q8VDQ8

Annotation

Keyword

Acetylation
Alternative splicing
Autophagy
Cell membrane
Cell projection
Chromosome
Cytoskeleton
Differentiation
Direct protein sequencing
Meiosis
Metal-binding
Microtubule
Mitosis
NAD
Neurogenesis
Nucleus
Phosphoprotein
Reference proteome
Transcription regulation
Transferase
Ubl conjugation
Zinc

Gene Ontology (GO)

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GO Term
paranode region of axon
juxtaparanode region of axon
myelin sheath
cytosol
perinuclear region of cytoplasm
centrosome
centriole
spindle
microtubule
growth cone

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
positive regulation of cell division
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of fat cell differentiation
negative regulation of DNA-templated transcription
cellular response to hypoxia
negative regulation of protein catabolic process
negative regulation of autophagy
negative regulation of peptidyl-threonine phosphorylation
cellular response to oxidative stress

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GO Term
chromatin binding
zinc ion binding
histone acetyltransferase binding
histone deacetylase activity
NAD-dependent histone deacetylase activity
protein lysine deacetylase activity
NAD-dependent protein deacetylase activity
histone deacetylase binding
ubiquitin binding
NAD-dependent histone H4K16 deacetylase activity

Annotation information from UniProt.

Sequence

MAEPDPSDPLETQAGKVQEAQDSDSDTEGGATGGEAEMDFLRNLFTQTLGLGSQKERLLDELTLEGVTRYMQSERCRKVICLVGAGISTSAGIPDFRSPSTGLYANLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTSCRKEYTMGWMKEKIFSEATPRCEQCQSVVKPDIVFFGENLPSRFFSCMQSDFSKVDLLIIMGTSLQVQPFASLISKAPLATPRLLINKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCDQGCLALADLLGWKKELEDLVRREHANIDAQSGSQAPNPSTTISPGKSPPPAKEAARTKEKEEQQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites