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NAD-dependent protein deacetylase sirtuin-2

Summary

UniProt ID

Q8VDQ8

Gene Symbol

Sirt2
Sir2l2

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q8VDQ8
PubChem: Q8VDQ8
The O-GlcNAc Database: Q8VDQ8
O-GlcNAcAtlas: Q8VDQ8

Annotation

Keyword

Acetylation
Alternative splicing
Autophagy
Cell membrane
Cell projection
Chromosome
Cytoskeleton
Differentiation
Direct protein sequencing
Meiosis
Metal-binding
Microtubule
Mitosis
NAD
Neurogenesis
Nucleus
Phosphoprotein
Reference proteome
Transcription regulation
Transferase
Ubl conjugation
Zinc

Gene Ontology (GO)

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GO Term
proteasome-mediated ubiquitin-dependent protein catabolic process
NLRP3 inflammasome complex assembly
negative regulation of transcription by RNA polymerase II
negative regulation of DNA-templated transcription
positive regulation of transcription by RNA polymerase II
protein deacetylation
negative regulation of peptidyl-threonine phosphorylation
epigenetic regulation of gene expression
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
peptidyl-lysine deacetylation

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GO Term
meiotic spindle
terminal loop
glial cell projection
glutamatergic synapse
mitotic spindle
growth cone
midbody
perikaryon
lateral loop
Schmidt-Lanterman incisure

Displaying entries **1 - 10** of 16 in total

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GO Term
NAD+ binding
NAD-dependent protein demyristoylase activity
NAD-dependent protein depalmitoylase activity
DNA-binding transcription factor binding
NAD-dependent histone deacetylase activity
NAD-dependent protein deacetylase activity
tubulin deacetylase activity
ubiquitin binding
NAD-dependent histone H4K16 deacetylase activity
NAD+ ADP-ribosyltransferase activity

Annotation information from UniProt.

Sequence

MAEPDPSDPLETQAGKVQEAQDSDSDTEGGATGGEAEMDFLRNLFTQTLGLGSQKERLLDELTLEGVTRYMQSERCRKVICLVGAGISTSAGIPDFRSPSTGLYANLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTSCRKEYTMGWMKEKIFSEATPRCEQCQSVVKPDIVFFGENLPSRFFSCMQSDFSKVDLLIIMGTSLQVQPFASLISKAPLATPRLLINKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCDQGCLALADLLGWKKELEDLVRREHANIDAQSGSQAPNPSTTISPGKSPPPAKEAARTKEKEEQQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites