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Fibroblast growth factor receptor substrate 2

Summary

UniProt ID

Q8WU20

Gene Symbol

FRS2

Gene ID

10818

Organism

Homo sapiens (human)

External Links

GlyGen: Q8WU20
PubChem: Q8WU20
The O-GlcNAc Database: Q8WU20
RaftProt: Q8WU20
O-GlcNAcAtlas: Q8WU20
Re-Glyco: Q8WU20

Annotation

Keyword

3D-structure
Membrane
Myristate
Phosphoprotein
Reference proteome
Ubl conjugation

Gene Ontology (GO)

Displaying **all 7** entries
GO Term
cytoplasm
plasma membrane
cell-cell junction
endomembrane system
membrane
cytosol
adherens junction

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 18 in total

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GO Term
G protein-coupled receptor signaling pathway
regulation of apoptotic process
regulation of epithelial cell proliferation
neuroblast proliferation
fibroblast growth factor receptor signaling pathway
anterior/posterior axis specification, embryo
organ induction
positive regulation of MAPK cascade
regulation of ERK1 and ERK2 cascade
positive regulation of vascular associated smooth muscle cell proliferation

Displaying **all 4** entries
GO Term
transmembrane receptor protein tyrosine kinase adaptor activity
neurotrophin TRKA receptor binding
phosphatase activator activity
fibroblast growth factor receptor binding

Annotation information from UniProt.

Sequence

MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQILLEPEGVKFVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPSVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRTALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIEYSRRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	GlyTouCan ID	Source
177	G49108TO	The O-GlcNAc Database
256		GlyGen
329	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 28 in total

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Pathway Name	Organism
Activated NTRK2 signals through FRS2 and FRS3	Homo sapiens
Constitutive Signaling by Aberrant PI3K in Cancer	Homo sapiens
FRS-mediated FGFR1 signaling	Homo sapiens
FRS-mediated FGFR2 signaling	Homo sapiens
FRS-mediated FGFR3 signaling	Homo sapiens
FRS-mediated FGFR4 signaling	Homo sapiens
Frs2-mediated activation	Homo sapiens
Negative regulation of FGFR1 signaling	Homo sapiens
Negative regulation of FGFR2 signaling	Homo sapiens
Negative regulation of FGFR3 signaling	Homo sapiens