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Fibroblast growth factor receptor substrate 2

Summary

UniProt ID: Q8WU20
Gene Symbol: FRS2
Gene ID: 10818
Organism: Homo sapiens (human)

External Links

GlyGen: Q8WU20
PubChem: Q8WU20
The O-GlcNAc Database: Q8WU20
RaftProt: Q8WU20
O-GlcNAcAtlas: Q8WU20
Re-Glyco: Q8WU20

Annotation

Keyword: 3D-structure Membrane Myristate Phosphoprotein Proteomics identification Reference proteome Ubl conjugation

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
gastrulation with mouth forming second
organ induction
ventricular septum development
cell surface receptor protein tyrosine phosphatase signaling pathway	TAS	PMID
G protein-coupled receptor signaling pathway	TAS	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

cell surface receptor protein tyrosine phosphatase signaling pathway

G protein-coupled receptor signaling pathway

cell population proliferation [inference]

neural precursor cell proliferation [inference]

neuroblast proliferation

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

lens fiber cell development

reproductive process [inference]

developmental process involved in reproduction [inference]

prostate gland epithelium morphogenesis [inference]

branching involved in prostate gland morphogenesis [inference]

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching involved in prostate gland morphogenesis [inference]

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

pattern specification process [inference]

axis specification [inference]

embryonic axis specification [inference]

anterior/posterior axis specification, embryo

anterior/posterior axis specification [inference]

anterior/posterior axis specification, embryo

embryonic pattern specification [inference]

embryonic axis specification [inference]

anterior/posterior axis specification, embryo

developmental process [inference]

developmental process involved in reproduction [inference]

prostate gland epithelium morphogenesis [inference]

branching involved in prostate gland morphogenesis [inference]

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching involved in prostate gland morphogenesis [inference]

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

embryonic morphogenesis [inference]

gastrulation [inference]

gastrulation with mouth forming second

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

prostate gland epithelium morphogenesis [inference]

branching involved in prostate gland morphogenesis [inference]

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

morphogenesis of a branching epithelium [inference]

branching involved in prostate gland morphogenesis [inference]

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

developmental induction [inference]

organ induction

anatomical structure formation involved in morphogenesis [inference]

ectodermal placode formation [inference]

lens placode formation [inference]

lens placode formation involved in camera-type eye formation

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

lens fiber cell development

animal gross anatomical part developmental process [inference]

cardiac septum development [inference]

ventricular septum development

forebrain development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

lens fiber cell development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of developmental process [inference]

positive regulation of animal organ morphogenesis [inference]

organ induction

positive regulation of multicellular organismal process [inference]

positive regulation of animal organ morphogenesis [inference]

organ induction

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of animal organ morphogenesis [inference]

regulation of animal organ formation [inference]

organ induction

positive regulation of animal organ morphogenesis [inference]

organ induction

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of striated muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiocyte differentiation [inference]

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of animal organ morphogenesis [inference]

organ induction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

cell surface receptor protein tyrosine phosphatase signaling pathway

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cell population proliferation [inference]

regulation of epithelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of striated muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiocyte differentiation [inference]

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of animal organ morphogenesis [inference]

organ induction

negative regulation of multicellular organismal process [inference]

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

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GO Term	Evidence Code	Reference
transmembrane receptor protein tyrosine kinase adaptor activity	TAS	PMID
transmembrane receptor protein tyrosine kinase adaptor activity	IBA	GO_REF
transmembrane receptor protein tyrosine kinase adaptor activity	IEA	GO_REF
fibroblast growth factor receptor binding	IBA	GO_REF
fibroblast growth factor receptor binding	IPI	PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

neurotrophin receptor binding [inference]

neurotrophin TRK receptor binding [inference]

neurotrophin TRKA receptor binding

receptor tyrosine kinase binding [inference]

transmembrane receptor protein tyrosine kinase adaptor activity

growth factor receptor binding [inference]

fibroblast growth factor receptor binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding [inference]

transmembrane receptor protein tyrosine kinase adaptor activity

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

signaling receptor complex adaptor activity [inference]

transmembrane receptor protein tyrosine kinase adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity

phosphatase regulator activity [inference]

phosphatase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQILLEPEGVKFVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPSVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRTALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIEYSRRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	PubMed ID	GlyTouCan ID	Source
177	31492838 35132862 38253038	G49108TO	The O-GlcNAc Database
256			GlyGen
329	31492838 35132862 38253038	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Activated NTRK2 signals through FRS2 and FRS3	Homo sapiens
Constitutive Signaling by Aberrant PI3K in Cancer	Homo sapiens
FRS-mediated FGFR1 signaling	Homo sapiens
FRS-mediated FGFR2 signaling	Homo sapiens
FRS-mediated FGFR3 signaling	Homo sapiens
FRS-mediated FGFR4 signaling	Homo sapiens
Frs2-mediated activation	Homo sapiens
Negative regulation of FGFR1 signaling	Homo sapiens
Negative regulation of FGFR2 signaling	Homo sapiens
Negative regulation of FGFR3 signaling	Homo sapiens

GlyTouCan

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