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MIRAGE
Frs2-mediated activation

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Activated TrkA receptor complexActive TrkA receptor:FRS2 complexFRS2ATPActive TrkA receptor:p-FRS2 complexADPCRKLActive TrkA receptor:p-FRS2:CRKL complexActive TrkA receptor:p-FRS2:CRKL:RAPGEF1C3GGTPRAP1:GTPGDPRAP1:GDPRAP1:GTP:B-Raf complexBRAF dimer complexRAP1:GTP:activated BRAF dimerRAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complexMAPKsMAP2K homo/heterodimersRAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complexRAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complexp-2S MAP2K homo/heterodimersp-T,Y MAPKsp-ERK dimerp-T,Y MAPK dimers
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
a simple tooltip
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: March 31, 2025