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A disintegrin and metalloproteinase with thrombospondin motifs 14
Summary
- UniProt ID
- Q8WXS8
- Gene Symbol
-
- ADAMTS14
- Gene ID
- 140766
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative promoter usage
- Alternative splicing
- Cleavage on pair of basic residues
- Collagen degradation
- Disulfide bond
- Extracellular matrix
- Glycoprotein
- Metal-binding
- Metalloprotease
- Proteomics identification
- Reference proteome
- Repeat
- Signal
- Zinc
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular matrix |
| GO Term |
|---|
| collagen fibril organization |
| collagen catabolic process |
| proteolysis |
| extracellular matrix organization |
| GO Term |
|---|
| metalloendopeptidase activity |
| metal ion binding |
Sequence
MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTPVPEDKGQPGEDLRHPGTSLPAASPVT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 109 | N-linked (GlcNAc...) asparagine |
|
||
| 475 | N-linked (GlcNAc...) asparagine |
|
||
| 941 | N-linked (GlcNAc...) asparagine |
|
||
| 1027 | N-linked (GlcNAc...) asparagine |
|
||
| 1116 |
|
|
||
| 1182 |
|
|
||
| 1211 |
|
|||
| 1214 |
|
|||
| 1220 |
|
G57321FI
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Collagen biosynthesis and modifying enzymes | Homo sapiens |
| Defective B3GALTL causes PpS | Homo sapiens |
| O-glycosylation of TSR domain-containing proteins | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050784 | primary progressive multiple sclerosis | |
| DOID:2378 | relapsing-remitting multiple sclerosis | |
| DOID:8398 | osteoarthritis |
