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Frizzled-4

Summary

UniProt ID

Q9ULV1

Gene Symbol

FZD4

Organism

Homo sapiens (human)

External Links

GlyConnect

2003

GlyGen

Q9ULV1

PubChem

Q9ULV1

The Human Metabolome Database

HMDBP07700

Annotation

Keyword

3D-structure
Cell membrane
Developmental protein
Disease variant
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix
Ubl conjugation
Wnt signaling pathway

Gene Ontology (GO)

Displaying entries **1 - 10** of 29 in total

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GO Term
positive regulation of cell migration
locomotion involved in locomotory behavior
extracellular matrix-cell signaling
progesterone secretion
endothelial cell differentiation
establishment of blood-brain barrier
retina vasculature morphogenesis in camera-type eye
retinal blood vessel morphogenesis
Norrin signaling pathway
positive regulation of neuron projection arborization

Displaying **all 6** entries
GO Term
dendrite
clathrin-coated endocytic vesicle membrane
glutamatergic synapse
cell surface
plasma membrane
cell-cell junction

Displaying entries **1 - 10** of 12 in total

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GO Term
signaling receptor activity
amyloid-beta binding
cytokine receptor activity
cytokine binding
ubiquitin protein ligase binding
protein homodimerization activity
Wnt receptor activity
protein-containing complex binding
protein heterodimerization activity
PDZ domain binding

Annotation information from UniProt.

Sequence

MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
59	N-linked (GlcNAc...) asparagine		G83460ZZ	UniProt GlyGen
144	N-linked (GlcNAc...) asparagine		G51413EV G22310AV G45395BF G40574BA G75983OB G48414YA G84452RH G63041LO	UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
Asymmetric localization of PCP proteins	Homo sapiens
Ca2+ pathway	Homo sapiens
Cargo recognition for clathrin-mediated endocytosis	Homo sapiens
Class B/2 (Secretin family receptors)	Homo sapiens
Clathrin-mediated endocytosis	Homo sapiens
Regulation of FZD by ubiquitination	Homo sapiens
Signaling by RNF43 mutants	Homo sapiens
WNT5A-dependent internalization of FZD4	Homo sapiens