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Receptor-interacting serine/threonine-protein kinase 3

Summary

UniProt ID

Q9Y572

Gene Symbol

RIPK3
RIP3

Organism

Homo sapiens (human)

External Links

GlyGen: Q9Y572
PubChem: Q9Y572
The Human Metabolome Database: HMDBP01148
The O-GlcNAc Database: Q9Y572
O-GlcNAcAtlas: Q9Y572

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Apoptosis
Cytoplasm
Host-virus interaction
Isopeptide bond
Necrosis
Nucleus
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 29 in total

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GO Term
regulation of type II interferon production
protein modification process
regulation of apoptotic process
defense response to virus
reactive oxygen species metabolic process
positive regulation of reactive oxygen species metabolic process
positive regulation of NF-kappaB transcription factor activity
positive regulation of necroptotic process
necroptotic process
programmed necrotic cell death

Displaying **all 4** entries
GO Term
protein-containing complex
cytosol
nucleus
cytoplasm

Displaying **all 7** entries
GO Term
transcription coactivator activity
protein kinase activity
protein serine/threonine kinase activity
ATP binding
identical protein binding
protein-containing complex binding
protein serine kinase activity

Annotation information from UniProt.

Sequence

MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	GlyTouCan ID	Source
346	G49108TO	GlyGen
416		GlyGen
467	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
IKK complex recruitment mediated by RIP1	Homo sapiens
Microbial modulation of RIPK1-mediated regulated necrosis	Homo sapiens
RIP-mediated NFkB activation via ZBP1	Homo sapiens
RIPK1-mediated regulated necrosis	Homo sapiens
Regulation of necroptotic cell death	Homo sapiens
SARS-CoV-1 activates/modulates innate immune responses	Homo sapiens
TICAM1, RIP1-mediated IKK complex recruitment	Homo sapiens
TLR3-mediated TICAM1-dependent programmed cell death	Homo sapiens
TRIF-mediated programmed cell death	Homo sapiens